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淫羊藿苷可抑制正畸致牙根的吸收
Icariin inhibits orthodontically induced inflammatory root resorption

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周艳妮 1   曹宝成 1   蒋小龙 2   曹帅 1  
文摘 背景:淫羊藿的主要成分之一淫羊藿苷对破骨细胞有抑制作用。目的:进一步验证淫羊藿苷对大鼠上颌第1磨牙近中根已形成的牙根吸收的影响。方法:建立大鼠左侧上颌正畸致牙根吸收模型,分别在左侧第1磨牙的颊侧骨膜上局部分别注射200 mg/kg的淫羊藿苷(淫羊藿苷组)或生理盐水(阳性对照组),所有大鼠的右侧上颌为阴性对照组,即不放置矫治器也不注射药物。测量安放矫治器前后双侧第1磨牙近中面到对侧上颌切牙远中面的距离,用扫描电镜观察拔除后双侧上颌第1磨牙的近中根的近中面。结果与结论:淫羊藿苷组大鼠上颌磨牙向近中移动量明显少于阳性对照组(P <0.05)。扫描电镜观察显示:淫羊藿苷组为散在小的吸收陷窝,阳性对照组牙根表面出现大量较大的吸收陷窝,并相互连成片状,与阴性对照组的光滑牙根面形成鲜明对比。说明淫羊藿苷可以抑制正畸致牙根吸收的发生,同时也减少了矫治力作用下磨牙的移动量。
其他语种文摘 BACKGROUND: Icari n as one of the main components of Epimedium has an inhibitory effect on osteoclasts.. OBJECTIVE: To further investigate the influence of icariin on the root absorption of the maxil ary first molar at mesial part during orthodontic treatment in rats. METHODS: Orthodontic root resorption models were established in the left maxil a of rats. Local injection of 200 mg/kg icari n (icari n group) or normal saline (positive control group) was administrated into the left first molar buccal periosteum. The right maxil a of rats served as negative control group that was treated with neither appliance nor drug injection. The mesial distance between bilateral first molars and the contralateral maxil ary incisor was measured before and after the appliance was placed. Mesial surface of the mesial root of bilateral maxil ary first molars was observed using scanning electron microscope. RESULTS AND CONCLUSION: Mesial movement of the maxil ary molars in the icari n group was significantly less than that in the positive control group (P < 0.05). Under the scanning electron microscope, smal absorption lacunae were scattered in the icari n group, while the positive control group showed a large amount of absorption lacunae and they were interconnected into a sheet, showing a stark contrast with the smooth root surface of the negative control group. It is indicated that icari n can inhibit root resorption caused by orthodontic treatment, while reducing the amount of mesial movement of the molar under corrective force.
来源 中国组织工程研究 ,2013,17(28):5171-5176 【扩展库】
关键词 组织构建 ; 口腔组织构建 ; 淫羊藿 ; 淫羊藿苷 ; 正畸致牙根吸收 ; 正畸 ; 牙根吸收 ; 上颌 ; 矫治器 ; 扫描电镜 ; 移动量 ; 第1磨牙
地址

1. 兰州大学口腔医学院正畸科, 甘肃, 兰州, 730000  

2. 甘谷县中医院, 甘肃, 甘谷, 741200

语种 中文
文献类型 研究性论文
ISSN 2095-4344
学科 基础医学
文献收藏号 CSCD:4893925

参考文献 共 29 共2页

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引证文献 2

1 刘志锋 淫羊藿苷抑制大鼠扩弓致牙根吸收过程中牙周组织TNF-α的表达 实用口腔医学杂志,2015,31(6):776-779
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2 崔跃 局部注射熊果酸对大鼠正畸牙移动和牙根吸收的减缓作用及其机制 吉林大学学报. 医学版,2016,42(2):231-235
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