帮助 关于我们

返回检索结果

CRF受体对五羟色胺系统的调节作用及早期环境因素的影响
The Roles of CRF Receptors in the Modulation of Serotoninergic System and the Effects of Early Environmental Factors

查看参考文献61篇

原三娜 1   王琼 2   邵枫 2   王玮文 1 *  
文摘 早期环境因素持续影响脑与行为的发展,增加个体成年后应激相关精神疾病患病的易感性。应激反应的中枢启动因子促肾上腺皮质激素释放因子(corticotropin-releasing factor,CRF)通过两种受体CRF1和CRF2调节中缝背核(dorsal raphe nucleus,DRN)-五羟色胺(serotonin,5-HT)系统,后者已被证实在应激相关情绪疾患发病和治疗过程中发挥重要作用。已知CRF受体以相互影响相互拮抗的方式动态调节DRN-5-HT系统,提示这两种受体相对作用的调节对于协调复杂环境中DRN-5-HT系统的应激反应过程起着关键性作用。早期环境因素和遗传因素交互作用导致CRF受体的分布和反应性持续改变并造成DRN-5-HT系统反应异常,可能是导致应激反应和精神疾病易感性个体差异的重要神经基础。
其他语种文摘 Early environmental factors had long-term effects on the development of brain and behaviors, and led to a variety of psychopathological changes. It is well known that the dorsal raphe nucleus (DRN)-serotonin (5-HT) system is implicated in the onset and treatment of stress-related psychiatric disorders. Corticotropin-releasing factor (CRF) modulates activity of this system during stress via activation of two receptors: CRF1 and CRF2. CRF1 and CRF2 mediated inhibition and excitation of the DRN-5-HT system respectively. Therefore, the regulation of the relative contribution of the two CRF receptors to brain CRF pathways may be essential in coordinating 5-HTergic responses to stress. The early environmental factors (e.g. stress) induced long-term even lifetime changes in the distribution and reactivity of CRF receptors, and the DRN-5-HT system response to further stressful stimuli, which might be involved in the individual differences of susceptibility to stress-related psychiatric disorders
来源 心理科学进展 ,2013,21(6):982-989 【核心库】
关键词 促肾上腺皮质激素释放激素 ; 早期环境因素 ; 中缝背核 ; 五羟色胺
地址

1. 中国科学院心理研究所, 中国科学院心理健康重点实验室, 北京, 100101  

2. 北京大学心理学系, 北京, 100871

语种 中文
文献类型 研究性论文
ISSN 1671-3710
学科 社会科学总论
基金 国家自然科学基金项目 ;  中国科学院知识创新工程项目 ;  中国科学院心理健康重点实验室、中国科学院心理研究所资助
文献收藏号 CSCD:4861690

参考文献 共 61 共4页

1.  Amat J. Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala. Neuroscience,2004,129(3):509-519 被引 2    
2.  Andersen S L. Stress, sensitive periods and maturational events in adolescent depression. Trends in Neurosciences,2008,31(4):183-191 被引 7    
3.  Arborelius L. Both long and brief maternal separation produces persistent changes in tissue levels of brain monoamines in middle-aged female rats. Neuroscience,2007,145(2):738-750 被引 6    
4.  Bale T L. CRF and CRF receptors: Role in stress responsivity and other behaviors. Annual Review of Pharmacology and Toxicology,2004,44:525-557 被引 10    
5.  Bledsoe A C. Anxiety states induced by post-weaning social isolation are mediated by CRF receptors in the dorsal raphe nucleus. Brain Research Bulletin,2011,85(3/4):117-122 被引 2    
6.  Bravo J A. Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders. International Journal of Neuropsychopharmacology,2011,14(5):666-683 被引 8    
7.  Brenes J C. Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum. Pharmacology Biochemistry and Behavior,2008,89(1):85-93 被引 3    
8.  Chalmers D. Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: Comparison with CRF1 receptor mRNA expression. The Journal of Neuroscience,1995,15(10):6340-6350 被引 6    
9.  Cirulli F. Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates. Neuroscience & Biobehavioral Reviews,2009,33(4):573-585 被引 6    
10.  Dalley J. Specific abnormalities in serotonin release in the prefrontal cortex of isolation-reared rats measured during behavioural performance of a task assessing visuospatial attention and impulsivity. Psychopharmacology,2002,164(3):329-340 被引 5    
11.  Day H E W. Differential expression of 5HT-1A, α_(1b) adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, γ-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. Journal of Comparative Neurology,2004,474(3):364-378 被引 1    
12.  Fone K C F. Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders. Neuroscience & Biobehavioral Reviews,2008,32(6):1087-1102 被引 11    
13.  Forster G L. Corticotropin-releasing factor in the dorsal raphe nucleus increases medial prefrontal cortical serotonin via type 2 receptors and median raphe nucleus activity. European Journal of Neuroscience,2008,28(2):299-310 被引 1    
14.  Fulford A J. Conditioned release of 5-hydroxytryptamine in vivo in the nucleus accumbens following isolation-rearing in the rat. Neuroscience,1998,83(2):481-487 被引 2    
15.  Gardner K L. Early life experience alters behavior during social defeat: Focus on serotonergic systems. Neuroscience,2005,136(1):181-191 被引 5    
16.  Gilmer W S. Early experience and depressive disorders: Human and non-human primate studies. Journal of Affective Disorders,2003,75(2):97-113 被引 6    
17.  Hauger R L. Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: New molecular targets. CNS & Neurological Disorders Drug Targets,2006,5(4):453-479 被引 7    
18.  Hensler Julie G. Serotonergic modulation of the limbic system. Neuroscience & Biobehavioral Reviews,2006,30(2):203-214 被引 3    
19.  Homberg J R. Deciphering the interaction of the CRF and serotonin brain systems in anxiety-related disorders. Journal of Neuroscience,2009,29(44):13743-13745 被引 1    
20.  Kirby L G. Regional differences in the effects of forced swimming on extracellular levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Brain Research,1995,682(1/2):189-196 被引 4    
引证文献 2

1 王倩 血管活性肠肽对帕金森病大鼠中缝背核5-HT、SP、CRF及CRFR2表达的影响 神经解剖学杂志,2015,31(5):611-616
被引 1

2 周瑞 促肾上腺皮质激素释放因子功能及其与帕金森病关系的研究进展 神经解剖学杂志,2017,33(6):758-762
被引 0 次

显示所有2篇文献

论文科学数据集
PlumX Metrics
相关文献

 作者相关
 关键词相关
 参考文献相关

版权所有 ©2008 中国科学院文献情报中心 制作维护:中国科学院文献情报中心
地址:北京中关村北四环西路33号 邮政编码:100190 联系电话:(010)82627496 E-mail:cscd@mail.las.ac.cn 京ICP备05002861号-4 | 京公网安备11010802043238号