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Synthesis and in vitro antitumor activity of novel diaryl urea derivatives

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文摘 A series of novel diaryl ureas containing 4-[(2-amino-6-trifluromethyl)pyrimidine-4-yl]piperazine-l-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib,some compounds showed more potent and a broader spectrum of anti-cancer activities.Among them,compound 2p demonstrated significant inhibitory activities against MDA-MB-231,HT-29 and MCF-7 cell lines with IC_(50) values of 0.016,0.63,0.001μmol/L, respectively.
来源 Chinese Chemical Letters ,2013,24(5):386-388 【核心库】
DOI 10.1016/j.cclet.2013.02.004
关键词 Diaryl ureas ; Synthesis ; Antitumor activity in vitro
地址

School of Pharmaceutical Engineering. Shenyang Pharmaceutical University, Key Lab of New Drugs Design and Discovery of Liaoning Province, Shenyang, 110016

语种 英文
文献类型 研究性论文
ISSN 1001-8417
学科 化学工业
基金 supported by a grant from the National Natural Science Foundation of China
文献收藏号 CSCD:4846555

参考文献 共 7 共1页

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引证文献 2

1 Nagarajan Sangaraiah An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents Chinese Chemical Letters,2014,25(3):419-422
被引 0 次

2 Wang Ke Synthesis and in vitro cytotoxic activities of sorafenib derivatives Chinese Chemical Letters,2014,25(5):702-704
被引 0 次

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