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Temporal effect of local hyperthermia on murine contact hypersensitivity

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文摘 Background The sensitization and elicitation phases are involved in the immunopathogenesis of contact hypersensitivity (CHS). Langerhans cells (LCs) are believed to play pivotal roles in the sensitization stage of CHS. Local hyperthermia on skin induces the migration as well as maturation of epidermal LCs. Although fever-range whole body hyperthermia and local hyperthermia at 43°C prior to sensitization were reported to suppress CHS, the effects of different temperatures and the timing sequence of local hyperthermia on CHS have not been tackled. Methods Local hyperthermia was applied to murine dorsal skin 3 days prior to, concurrent with, or 2 days post sensitization with fluorescein isothiocyanate (FITC) in BALB/c mice. Local hyperthermia temperatures at 37°C, 39°C, 41°C and 43°C were applied to mouse dorsal skin and the severity of CHS was calculated by measuring the swelling response of the challenged ears. Results Local hyperthermia at 39°C, 41°C and 43°C prior to sensitization reduced the severity of CHS, as compared with that at 37°C. The suppression of CHS was temperature dependant in that higher temperature had a stronger effect. On the contrary, the hyperthermia treatments, either concurrent with or post-sensitization, resulted in an enhanced temperature-dependant ear swelling response. Conclusions The severity of murine CHS could be influenced by local hyperthermia at the sensitization stage in a temperature dependant manner. The temporal effect of local hyperthermia suggested a novel factor in interpreting the severity of allergic contact dermatitis.
来源 Chinese Medical Journal ,2013,126(8):1555-1559 【核心库】
DOI 10.3760/cma.j.issn.0366-6999.20123030
关键词 fever ; dermatitis, contact ; Langerhans cells ; immunization
地址

1. Department of Dermatology, No. 1 Hospital of China Medical University, Liaoning, Shenyang, 110001  

2. Department of Dermatology, Fifth Affiliated Hospital of SunYat-sen University, Guangdong, Zhuhai, 519000

语种 英文
文献类型 研究性论文
ISSN 0366-6999
学科 皮肤病学与性病学
基金 国家自然科学基金 ;  Innovative Research Teams in Universities, Ministry of Education ;  Liaoning Bureau
文献收藏号 CSCD:4808214

参考文献 共 20 共1页

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引证文献 1 篇

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