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Characterization of erythromycin-resistant Streptococcus pneumoniae isolates causing invasive diseases in Chinese children

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文摘 Background Erythromycin-resistant Streptococcus pneumoniae isolates that causing invasive pneumococcal diseases (IPD) in Chinese children remain uncharacterized. This study aims to identify the resistance genes associated with erythromycin resistance and to determine the genetic relationships of IPD isolates in Chinese children. Methods A total of 171 S. pneumoniae strains were isolated from 11 medical centers in China from 2006 to 2008. All the isolates were characterized via serotyping and antibiotic susceptibility determination. The erythromycin-resistant isolates were further characterized via ermB and mefA gene detection, multi-locus sequence typing analysis, and pulsed-field gel electrophoresis. Results A total of 164 (95.9%) isolates showed resistance to erythromycin, of which 162 strains with high high-level resistance (MIC ≥ 256 μg/ml). A total of 104 (63.4%) isolates carry the ermB gene alone, whereas 59 (36.0%) harbor both ermB and mefA genes. Of the 59 strains, 54 were of serotypes 19A and 19F and were identified as highly clonal and related to the Taiwan~(19F)-14 clone. Conclusions The erythromycin resistance rate in IPD isolates is significantly high and is predominantly mediated by the ermB gene. Isolates that carry both ermB and mefA genes are predominantly of serotypes 19A and 19F.
来源 Chinese Medical Journal ,2013,126(8):1522-1527 【核心库】
DOI 10.3760/cma.j.issn.0366-6999.20122185
关键词 Streptococcus pneumonia ; invasive pneumococcal diseases ; erythromycin ; resistance ; genes
地址

1. Beijing Pediatrics Research Institute, Beijing Children’s Hospital, (Capital Medical University), Key Laboratory of Major Diseases in Children and the National Key Discipline of Pediatrics, Ministry of Education, Beijing, 100045  

2. Lanzhou Institute of Biological Products, Gansu, Lanzhou, 730030  

3. Shenzhen Children’s Hospital, Guangdong, Shenzhen, 518000  

4. Pediatric Hospital of Fudan University, Shanghai, 200102  

5. Shengjing Hospital Affiliated to China Medical University, Liaoning, Shenyang, 110100  

6. Nanjing Children’s Hospital, Jiangsu, Nanjing, 210000  

7. Tianjin Children’s Hospital, Tianjin, 300000  

8. Chongqing Children’s Hospital Affiliated to Chongqing Medical University, Chongqing, 401000  

9. Yuying Children’s Hospital Affiliated to Wenzhou Medical College, Zhejiang, Wenzhou, 325500  

10. Soochow University Pediatric Hospital, Jiangsu, Suzhou, 215400  

11. Anhui Medical University Affiliated Hospital, Anhui, Hefei, 230100  

12. First Affiliated Hospital of Xinjiang Medical University, Xinjiang, Urumqi, 830000

语种 英文
文献类型 研究性论文
ISSN 0366-6999
学科 儿科学
基金 supported by the grants from Beijing Nova Program ;  the Special Fund for High-level Personnel Development in the Beijing Health System ;  the Beijing Guidance Teacher Technology Item of Excellent Doctorship Thesis
文献收藏号 CSCD:4808208

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