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Influence of 5-HTTLPR genotypes on structural and functional connectivity within amygdala-prefrontal cortex circuitry

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Xu Ke 1 *   Wang Fei 2 *  
文摘 Anxiety and depression are highly heritable disorders that lead to significant impairment in affected individuals across gender,ethnicity and race;these disorders are frequently the leading causes of disability and suicide in many countries.One could assume that the same pathophysiological mechanisms underlie anxiety and depression in all affected individuals; however, the observed clinical heterogeneity within these disorders raises doubts and questions as to the validity of this assumption. Moreover, no single gene is thought to underlie anxiety and depression. Instead, it is thought that a convergence of multiple genetic factors contributes to the clinical manifestations of these disorders, adding yet another layer of complexity to understanding the pathophysiology of anxiety and depression.
来源 Neuroscience Bulletin ,2013,29(1):1-2 【核心库】
DOI 10.1007/s12264-013-1302-6
地址

1. Department of Radiology, The First Affiliated Hospital, China Medical University, Shenyang, 110001  

2. Department of Psychiatry, Yale University School of Medicine, USA, New Haven, 06511

语种 英文
文献类型 研究性论文
ISSN 1673-7067
学科 基础医学
文献收藏号 CSCD:4784523

参考文献 共 19 共1页

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