微重力效应对骨髓间充质干细胞增殖分化影响的研究进展
Progress of microgravity effects on proliferation and differentiation of bone marrow mesenchymal stem cells
查看参考文献29篇
|
文摘
|
力学刺激对细胞的生长和功能起着重要调节作用。随着空间生命科学与空间生物技术的迅速发展，空间条件下细胞的生物学行为特征、规律及其相关分子机理逐渐成为空间生物学研究的热点和前沿。骨髓间充质干细胞（bonemarrowmesenchymalstemcells,MSCs）是一种具有自我更新和多向分化潜能的多能干细胞，在组织修复中起重要作用，是临床细胞治疗的主要材料。近年来，人们利用空间模拟技术在细胞响应微重力环境的生物学特征研究方面取得了重要进展。本文介绍了目前常用的几种地基微重力效应模拟装置，结合相关研究成果对微重力作用下MSCs增殖、分化行为的改变及其相关的分子机理进行简要综述，为预防和治疗微重力相关疾病提供理论参考。 |
|
其他语种文摘
|
Mechanical stimulation plays key roles in regulating the development and function of cells. With the rapid progress of space life science and space biotechnology, the biological behaviors of cells and the involved molecular mechanisms in space have gradually become a hot topic and frontier of the space biology. Bone marrow mesenchymal stem cells (MSCs) plays an important part in clinical cytotherapy and wound healing, due to its self renewal and multi-lineage differentiation potentials. In recent years, researchers have made significant achievements in biological behaviors of cells responding to microgravity environment by means of space simulation technology. In this review, some commonly used microgravity simulation devices were introduced, and changes in MSCs proliferation and differentiation under microgravity and its related molecular mechanisms were briefly summarized, so as to provide theoretical references for prevention and treatment of microgravity related diseases. |
|
来源
|
医用生物力学
,2013,28(1):121-126 【核心库】
|
|
关键词
|
微重力
;
间充质干细胞
;
细胞增殖
;
细胞分化
;
空间生物力学
|
|
地址
|
1.
重庆大学生物工程学院, 生物流变科学与技术教育部重点实验室, 重庆, 400044
2.
重庆大学生物工程学院, 生物流变科学与技术教育部重点实验室;;中国科学院微重力重点实验室, 重庆, 400044
|
|
语种
|
中文 |
|
文献类型
|
综述型 |
|
ISSN
|
1004-7220 |
|
学科
|
基础医学 |
|
基金
|
中国科学院微重力重点实验室2012年度开放课题
;
国家自然科学基金资助项目
|
|
文献收藏号
|
CSCD:4771253
|
参考文献 共
29
共2页
|
|
1.
任维. 空间生命科学发展的回顾、动态和展望.
空间科学学报,2000,20(10):48-55
|
被引
7
次
|
|
|
|
|
2.
Okada A. Kidney stone formation during space flight and long-term bed rest.
Clin Calcium,2011,21(10):1505-1510
|
被引
3
次
|
|
|
|
|
3.
Wiener T C. Space obstructive syndrome: Intracranial hypertension, intraocular pressure, and papilledema in space.
Aviat Space Environ Med,2012,83(1):64-66
|
被引
4
次
|
|
|
|
|
4.
Thiel C S. Rapid alterations of cell cycle control proteins in human T lymphocytes in microgravity.
Cell Commun Signal,2012,10(1):1
|
被引
3
次
|
|
|
|
|
5.
Battista N. 5-Lipoxygenase-de-pendent apoptosis of human lymphocytes in the international space station: Data from the ROALD experiment.
FASEB J,2012,26(5):1791-1798
|
被引
4
次
|
|
|
|
|
6.
Pittenger M F. Multilineage potential of adult human mesenchymal stem cells.
Science,1999,284(5411):143-147
|
被引
1927
次
|
|
|
|
|
7.
于波. 力学因素在间充质干细胞构建功能性组织工程化软骨中的作用.
医用生物力学,2011,26(5):482-486
|
被引
6
次
|
|
|
|
|
8.
Engler A J. Matrix elasticity directs stem cell lineage specification.
Cell,2006,126(4):677-689
|
被引
238
次
|
|
|
|
|
9.
Stolberg S. Can shear stress direct stem cell fate.
Biotechnol Prog,2009,25(1):10-19
|
被引
2
次
|
|
|
|
|
10.
袁琳. ERK信号分子介导周期机械拉伸诱导的骨髓间充质干细胞增殖.
医用生物力学,2011,26(3):217-224
|
被引
8
次
|
|
|
|
|
11.
刘承宪. 21世纪空间生命科学和空间生物技术发展机遇与挑战.
空间科学学报,2000,20(S1):37-47
|
被引
1
次
|
|
|
|
|
12.
齐乃明. 空间微重力环境地面模拟试验方法综述.
航天控制,2011,29(3):95-100
|
被引
36
次
|
|
|
|
|
13.
夏益霖. 微重力落塔试验技术及其应用（1）.
强度与环境,1995,22(2):17-21
|
被引
1
次
|
|
|
|
|
14.
张孝谦. 国家微重力实验室百米落塔实验设施的几项关键技术.
中国科学E辑,2005,35(5):523-534
|
被引
8
次
|
|
|
|
|
15.
Consolo F. Computational modeling for the optimization of a cardiogenic 3D biopro-cess of encapsulated embryonic stem cells.
Biomech Model Mechanobiol,2012,11(1/2):261-277
|
被引
5
次
|
|
|
|
|
16.
Herranz R. Microgravity simulation by diamagnetic levitation: Effects of a strong gradient magnetic field on the transcriptional profile of drosophila melanogaster.
BMC Genomics,2012,13(1):52
|
被引
7
次
|
|
|
|
|
17.
Pan Z. Effects of hindlimb unloading on ex vivo growth and osteogenic/adipogenic potentials of bone marrow-derived mesenchymal stem cells in rats.
Stem Cells Dev,2008,17(4):795-804
|
被引
6
次
|
|
|
|
|
18.
Zayzafoon M. Modeled microgravity inhibits osteogenic differentiation of human mesenchymal stem cells and increases adipogenesis.
Endocrinology,2004,145(5):2421-2432
|
被引
44
次
|
|
|
|
|
19.
Huang Y. Gravity,a regulation factor in the differentiation of rat bone marrow mesenchymal stem cells.
J Biomed Sci,2009,16:87
|
被引
20
次
|
|
|
|
|
20.
Dai Z Q. Simulated microgravity inhibits the proliferation and osteogenesis of rat bone marrow mesenchymal stem cells.
Cell Prolif,2007,40(5):671-684
|
被引
33
次
|
|
|
|
|
了解气象卫星更多信息，请访问