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基于运动想象的脑机交互康复训练新技术对脑卒中大脑可塑性影响
A new technique of rehabilitation training based on motor imagine using brain computer interface-func? tional electric stimulation system and it's effect on plasticity of brain of a stroke patient

查看参考文献27篇

刘小燮 1   毕胜 1 *   高小榕 2   杨志 3   闫铮 2   寇程 1   马林 4   高上凯 2  
文摘 目的:验证脑机接口结合功能性电刺激(BCI-FES)在中枢神经康复中的可行性及其机制。方法:对1例40岁男性脑卒中后左侧上肢重度瘫痪患者进行4周的基于运动想象的BCI-FES训练,训练前后各进行一次系统上肢功能评价及包含"运动"及"想象"组块的fMRI检测,进行功能激活图的绘制。结果:经过为期1个月的训练后左手最快抓握速度提高24.7%,左手抓握运动时功能性磁共振成像(fMRI)激活表现为出现病灶同侧主要运动区(M1)及辅助运动区(SMA)的激活,病灶对侧M1区及运动前区(PMC)激活较训练前减弱。左手运动想象任务时出现了双侧SMA及病灶同侧右后顶叶的激活。结论:脑机交互技术可促进脑卒中患者的中枢神经重塑。BCI-FES应用于存在脑损伤的脑卒中患者的康复训练是可行的。
其他语种文摘 Objective: To study the feasibility of brain computer interface combined with functional electric stimulation (BCI-FES) applied to a patient with stroke as a new rehabilitation training system and to explore its mechanism. Method: The participant was a 40 years old man with severe left-hand paralysis after stroke. He received 4 weeks training with BCI-FES system based on motor imagine. The motor function of upper limb was assessed and fMRI examination was conducted pre- and after training. Result: Maximum grasp-relax speed of affected hand increased by 24.7% after training. When motion task was executed the activations in primary motor area(M1) and supplement motor area(SMA) of ipsilateral hemisphere were observed with fMRI after training, and contralateral activations in M1 and premotor cortex(PMC) decreased in addition. When motor imagine task was executed, the activations transferred to bilateral SMA and ipsilateral posterior parietal after BCI training. Conclusion: BCI-FES was a kind of feasible rehabilitation therapy for stroke survivor. The mechanism of functional recovery by using BCI-FES was to promote the plasticity of central nervous system.
来源 中国康复医学杂志 ,2013,28(2):97-102 【核心库】
DOI 10.3969/j.issn.1001-1242.2013.02.001
关键词 脑卒中 ; 脑机接口 ; 运动想象 ; 功能性核磁共振 ; 大脑可塑性
地址

1. 中国人民解放军总医院康复医学中心, 北京, 100853  

2. 清华大学医学院生物医学工程系神经工程研究所  

3. 中国科学院心理研究所, 中国科学院行为科学重点实验室  

4. 中国人民解放军总医院放射科

语种 中文
文献类型 研究性论文
ISSN 1001-1242
学科 临床医学;神经病学与精神病学
基金 国家自然科学基金面上项目
文献收藏号 CSCD:4763351

参考文献 共 27 共2页

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引证文献 22

1 刘小燮 中国脑机接口研究发展及现状——基于中国期刊全文数据库的文献计量分析 中华物理医学与康复杂志,2014,36(5):381-385
被引 0 次

2 刘小燮 脑机接口技术的康复应用及研究进展 中国康复医学杂志,2014,29(10):982-986
被引 5

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