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罗勒籽脂肪酸及其对蛋白酪氨酸磷酸酯酶1B(PTP1B)抑制作用的研究
Component and PTP1B Inhibition of Fatty Acid from Seeds of Ocimum basilicum L

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文摘 利用索氏提取法提取罗勒籽油,向罗勒籽油加入氢氧化钾甲醇溶液后并用水浴加热,加入正己烷和蒸馏水萃取,上清液即为罗勒籽油中脂肪酸,用气相色谱质谱法(GC/MS)对脂肪酸进行鉴定。共鉴定出了4种脂肪酸,其中α-亚麻酸为62.88%、亚油酸为20.66%、棕榈酸为10.67%、硬脂酸为5.79%。对罗勒籽脂肪酸进行PTP1B的抑制作用研究,结果表明脂肪酸对PTP1B有较强的抑制作用,其IC_(50)为11.12μg/mL。该研究为深入研究罗勒籽的药理作用提供了科学依据。
其他语种文摘 Fats and oil were extracted by Soxhlet extraction from the seeds of Ocimum basilicum L.. And then fats and oil were dissolved in KOH of methonal with water-bath. Lastly,the fatty acids were extracted with n-hexane. The chemical constituents of the fatty acids were identified and quantified by means of capillary gas chromatography combined gas Chromatography-mass spectrometry. The results indicated that the fatty acids included four kinds of fatty acids: α-linolenic acid (62. 88%),linoleic acid (20. 66%),hexadecanoic acid (10. 67%) and octadecanoic acid (5. 79%). The fatty acids had strong inhibiting effect on PTP1B with IC_(50) value of 11. 12 μg /mL. The results provided the basis for further study of the seeds of O. basilicum.
来源 天然产物研究与开发 ,2012,24(9):1261-1263,1302 【核心库】
关键词 罗勒籽 ; 脂肪酸 ; 气相色谱/质谱 ; PTP1B抑制作用
地址

1. 中国科学院新疆理化技术研究所, 乌鲁木齐, 830011  

2. 新疆医科大学药学院, 乌鲁木齐, 830054

语种 中文
ISSN 1001-6880
学科 化学
基金 新疆科技基础条件平台建设项目 ;  新疆特有药用资源利用省部共建实验室
文献收藏号 CSCD:4746949

参考文献 共 17 共1页

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