人脑功能连接组:方法学、发展轨线和行为关联
The human functional connectome: Its methodology, developmental trajectory and behavioral association
查看参考文献144篇
文摘
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人脑内部功能连接的全体称为功能连接组,其功能复杂性表现在:(ⅰ)结构到功能的产生机制;(ⅱ)脑功能到心理行为的产生机制(心脑关联);(ⅲ)整个生命历程中的功能发展轨线.一直以来,神经科学家致力于揭示人脑功能在不同生命历程阶段的特征及其深层机制.上述问题的研究能够极大地改善对人脑功能的理解,改进长期以来必须依赖于动物脑功能模型的状况,为重大神经精神疾病的脑功能的病理生理机制研究提供正常参考(常模),进而有助于及时、准确地对其进行诊断、预警、干预和后期评价.但限于实验技术和计算方法,与脑功能有关的上述问题因极具挑战性而尚未被系统地展开研究;静息态功能磁共振技术的出现正在改变人脑功能的研究现状.本文综述基于静息态功能磁共振技术研究人脑功能连接组的计算方法及其重测信度、功能发展轨线应用、心理行为关联. |
其他语种文摘
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The whole brain functional network is conceptualized as the human functional connectome. The complexity of its function is reflected in: (1) the functioning mechanism based upon its structure, (2) the principle of brain-mind association, and (3) the delineation of its life-span trajectory. All along, the neuroscientists committed to reveal the characteristics of the underlying mechanisms of human brain function in different stages of the life course. Progresses in the above-mentioned problems can greatly improve the understanding of human brain function, advance the long reality that it must rely on the animal models, to provide normal reference (norm) for the study of the pathophysiology of major neuropsychiatric diseases of brain function, and thus contribute to the timely, accurate diagnosis, early warning, intervention and treatment post-evaluation of brain disorders. However, limited to the experimental techniques and computational methods, these problems have been extremely challenging and not been systematically studied. Fortunately, resting state functional magnetic resonance imaging (R-fMRI) is rapidly changing this status of the research of human brain function. This paper reviews various R-fMRI computational methods and their test-retest reliability, the functional development trajectory of the connectome and relevant psychological and behavioral association. |
来源
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科学通报
,2012,57(35):3399-3413 【核心库】
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关键词
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人脑功能连接组
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静息态磁共振
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重测信度
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发展轨线
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心脑关联
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地址
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1.
中国科学院心理研究所功能连接组与发展实验室磁共振研究中心, 中国科学院行为科学重点实验室, 北京, 100101
2.
中国科学院大学, 中国科学院行为科学重点实验室, 北京, 100049
3.
北京师范大学脑与认知科学研究院, 认知神经科学与学习国家重点实验室, 北京, 100875
4.
杭州师范大学附属医院认知与脑疾病研究中心, 杭州, 310015
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语种
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中文 |
ISSN
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0023-074X |
学科
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社会科学总论 |
基金
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国家科技支撑计划项目
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国家自然科学基金
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中国科学院心理研究所特聘研究员基金
;
中国科学院心理研究所行为科学重点实验室开放课题基金资助
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文献收藏号
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CSCD:4718690
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参考文献 共
144
共8页
|
1.
Giedd J N. Development of the human corpus callosum during childhood and adolescence: A longitudinal MRI study.
Prog Neuropsychopharmacol Biol Psychiatry,1999,23:571-588
|
被引
7
次
|
|
|
|
2.
Giedd J N. Anatomical brain magnetic resonance imaging of typically developing children and adolescents.
J Am Acad Child Adolesc Psychiatry,2009,48:465-470
|
被引
2
次
|
|
|
|
3.
Giedd J N. Structural MRI of pediatric brain development: What have we learned and where are we going?.
Neuron,2010,67:728-734
|
被引
6
次
|
|
|
|
4.
Waber D P. The NIH MRI study of normal brain development: Performance of a population based sample of healthy children aged 6 to 18 years on a neuropsychological battery.
J Int Neuropsychol Soc,2007,13:729-746
|
被引
4
次
|
|
|
|
5.
Almli C R. The NIH MRI study of normal brain development (Objective-2): Newborns, infants, toddlers, and preschoolers.
NeuroImage,2007,35:308-325
|
被引
1
次
|
|
|
|
6.
Evans A C. The NIH MRI study of normal brain development.
NeuroImage,2006,30:184-202
|
被引
5
次
|
|
|
|
7.
Biswal B. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.
Magn Reson Med,1995,34:537-541
|
被引
246
次
|
|
|
|
8.
Fox M D. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.
Nat Rev Neurosci,2007,8:700-711
|
被引
129
次
|
|
|
|
9.
Biswal B B. Toward discovery science of human brain function.
Proc Natl Acad Sci USA,2010,107:4734-4739
|
被引
45
次
|
|
|
|
10.
Sporns O. The human connectome: A structural description of the human brain.
PLoS Comput Biol,2005,1:e42
|
被引
70
次
|
|
|
|
11.
Nakagawa S. Repeatability for Gaussian and non-Gaussian data: A practical guide for biologists.
Biol Rev Camb Philos Soc,2010,85:935-956
|
被引
7
次
|
|
|
|
12.
Barnhart H X. An overview on assessing agreement with continuous measurements.
J Biopharm Stat,2007,17:529-569
|
被引
2
次
|
|
|
|
13.
Bennett C M. How reliable are the results from functional magnetic resonance imaging?.
Ann NY Acad Sci,2010,1191:133-155
|
被引
11
次
|
|
|
|
14.
Raichle M E. Brain work and brain imaging.
Annu Rev Neurosci,2006,29:449-476
|
被引
29
次
|
|
|
|
15.
Ter-Pogossian M M. A positron-emission transaxial tomograph for nuclear imaging (PETT).
Radiology,1975,114:89-98
|
被引
4
次
|
|
|
|
16.
Ogawa S. Brain magnetic resonance imaging with contrast dependent on blood oxygenation.
Proc Natl Acad Sci USA,1990,87:9868-9872
|
被引
195
次
|
|
|
|
17.
Greicius M D. Functional connectivity in the resting brain: A network analysis of the default mode hypothesis.
Proc Natl Acad Sci USA,2003,100:253-258
|
被引
180
次
|
|
|
|
18.
Broyd S J. Default-mode brain dysfunction in mental disorders: A systematic review.
Neurosci Biobehav Rev,2009,33:279-296
|
被引
40
次
|
|
|
|
19.
Greicius M. Resting-state functional connectivity in neuropsychiatric disorders.
Curr Opin Neurol,2008,21:424-430
|
被引
18
次
|
|
|
|
20.
Fornito A. What can spontaneous fluctuations of the blood oxygenation-level-dependent signal tell us about psychiatric disorders?.
Curr Opin Psychiatry,2010,23:239-249
|
被引
2
次
|
|
|
|
|