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Altered regional homogeneity in post-traumatic stress disorder: a resting-state functional magnetic resonance imaging study

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文摘 Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder (PTSD). Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging (fMRI), between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Methods Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent (BOLD) fMRI and analyzed using the measure of regional homogeneity (ReHo) during the resting state. Results PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Conclusion Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD.
来源 Neuroscience Bulletin ,2012,28(5):541-549 【核心库】
DOI 10.1007/s12264-012-1261-3
关键词 functional magnetic resonance imaging ; post-traumatic stress disorder ; regional homogeneity ; resting-state
地址

1. Mental Health Institute, The Second Xiangya Hospital of Central South University, Changsha, 410011  

2. Department of Psychiatry, University of California–San Diego School of Medicine, USA, San Diego  

3. Guangdong Mental Health Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510120  

4. Mianzhu Psychiatric Hospital, Deyang, 618200  

5. Mental Health Center of Sichuan Province, Mianyang, 621000  

6. Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049  

7. Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041

语种 英文
ISSN 1673-7067
学科 神经病学与精神病学
基金 国家自然科学基金 ;  the National Science and Technology Program of China ;  the National Basic Research Development Program (973 Program) of China ;  the Science and Technology Program of the Ministry of Education, China ;  国家863计划
文献收藏号 CSCD:4680713

参考文献 共 59 共3页

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