Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats
查看参考文献28篇
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文摘
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Aim: To compare the pharmacokinetic parameters of cefuroxime lysine, a new second-generation of cephalosporin antibiotics, after intravenous (IV), intraperitoneal (IP), or intramuscular (IM) administration. Methods: Twelve male and 12 virgin female Sprague-Dawley rats, weighing from 200 to 250 g, were divided into three groups (n=4 for each gender in each group). The rats were administered a single dose (67.5 mg/kg) of cefuroxime lysine via IV bolus or IP or IM injection. Blood samples were collected and analyzed with a validated UFLC-MS/MS method. The concentration-time data were then calculated by compartmental and non-compartmental pharmacokinetic methods using DAS software. Results: After IV, IP or IM administration, the plasma cefuroxime lysine disposition was best described by a tri-compartmental, bi-compartmental or mono-compartmental open model, respectively, with first-order elimination. The plasma concentration profiles were similar through the 3 administration routes. The distribution process was rapid after IV administration: the value of t_(1/2(d)) was 0.10±0.11 h, 1.36±0.65 h, and 1.25±1.01 h after IV, IP or IM administration. The AUMC_(0-∞) is markedly larger, and mean residence time (MRT) is greatly longer after IP administration: the value of AUMC_(0-∞) was 16.84±4.85, 55.33±20.34, and 36.17±13.24 mg·h~2/L; the value of MRT was 0.37±0.07 h, 0.93±0.10 h, and 0.65±0.05 h after IV, IP or IM administration. The C_(max) after IM injection was significantly higher than that in IP injection (73.51±12.46 vs 49.09±7.06 mg/L). There was no significantly sex-related difference in other pharmacokinetic parameters of cefuroxime lysine between male and female rats, except the value of AUC_(0-∞) via IM administration that was significantly larger in male rats than that in female rats (66.38±16.5 vs 44.23±6.37 mg·h/L). Conclusion: Cefuroxime lysine shows quick absorption after IV injection, a long retension after IP injection, and a high C_(max) after IM injection. After IM administration the AUC_(0-∞) in male rats was significantly larger than that in female rats. |
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来源
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Acta Pharmacologica Sinica
,2012,33(11):1348-1352 【核心库】
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DOI
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10.1038/aps.2012.99
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关键词
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cefuroxime lysine
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intravenous administration
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intramuscular administration
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intraperitoneal administration
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pharmacokinetics
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地址
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School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016
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语种
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英文 |
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ISSN
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1671-4083 |
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学科
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药学 |
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基金
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supported by the National Key Scientific Project for New Drug Discovery and Development
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文献收藏号
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CSCD:4669573
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参考文献 共
28
共2页
|
|
1.
Vazquez J C. Treatments for symptomatic urinary tract infections during pregnancy.
Cochrane Database Syst Rev,2011(1):CD002256
|
被引
1
次
|
|
|
|
|
2.
Bae S. Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance.
Antimicrob Agents Chemother,2010,54:65-71
|
被引
7
次
|
|
|
|
|
3.
Bischoff M. Pharmacokinetics of cefuroxime in traumatic wound secretion and antibacterial activity under vacuum therapy.
J Chemother,2010,22:92-97
|
被引
1
次
|
|
|
|
|
4.
Asiri Y A. Comparative bioavailability study of cefuroxime axetil (equivalent to 500 mg cefuroxime/table) tablets (Zednad? versus Zinnat?) in healthy male volunteers.
Int J Clin Pharmacol Ther,2011,49:571-576
|
被引
1
次
|
|
|
|
|
5.
Ruiz-Carretero P. Pharma-cokinetic models for the saturable absorption of cefuroxime axetil and saturable elimination of cefuroxime.
Eur J Pharm Sci,2004,21:217-223
|
被引
4
次
|
|
|
|
|
6.
Abo El-sooud K. Pharmacokinetics and intramuscular bioavailability of cefuroxime sodium in goats.
Res Vet Sci,2000,69:219-224
|
被引
2
次
|
|
|
|
|
7.
Chaudhary R K. Modification of the pharma-cokinetics and dosage of cefuroxime by endotoxin-induced fever in buffalo calves.
Vet Res Commun,1999,23:361-368
|
被引
1
次
|
|
|
|
|
8.
Zhao L S. A fast, sensitive, and high throughput method for the determination of cefuroxime lysine in dog plasma by UPLC-MS/MS.
Talanta,2012,89:84-90
|
被引
4
次
|
|
|
|
|
9.
Viberg A. Determination of cefuroxime in human serum or plasma by liquid chromatography with electrospray tandem mass spectrometry.
Rapid Commun Mass Spectrom,2004,18:707-710
|
被引
4
次
|
|
|
|
|
10.
Zhao L S. Determination of cefuroxime in liver-injured rat plasma by ultra-fast liquid chromatography-tandem mass spectrometry via acidified protein precipitation.
Chin J Chromatogr,2012
|
被引
1
次
|
|
|
|
|
11.
Yamaoka K. Statistical moments in pharmacokientics.
J Pharmacokinet Biopharm,1978,6:547-558
|
被引
9
次
|
|
|
|
|
12.
Grasso S. New in vitro model to study the effect of antibiotic concentration and rate of elimination on antibacterial activity.
Antimicrob Agents Chemother,1978,13:570-576
|
被引
3
次
|
|
|
|
|
13.
Murakawa T. New in vitro kinetic model for evaluting bactericidal efficacy of antibiotics.
Antimicrob Agents Chemother,1980,18:377-381
|
被引
2
次
|
|
|
|
|
14.
Gibaldi M.
Pharmacokinetics, second ed,1982
|
被引
1
次
|
|
|
|
|
15.
Chen M L. Tissue metabolism and distribution of methotrexate in rabbits.
Drug Metab Dispos,1982,10:706-707
|
被引
1
次
|
|
|
|
|
16.
Dimitrova D. Pharmacokinetics of tobramycin in ducks and sex-related differences.
Vet J,2009,179:462-464
|
被引
1
次
|
|
|
|
|
17.
Powers J. Statistical analysis of pharmacokinetics data.
J Vet Pharmacol Ther,1990,13:113-120
|
被引
2
次
|
|
|
|
|
18.
Snedecor G W.
Statistical Methods, seventh ed,1980:39-63
|
被引
1
次
|
|
|
|
|
19.
Gower P E. The pharmacokinetics of cefuroxime after intravenous injection.
Eur J Clin Pharmacol,1977,12:221-227
|
被引
2
次
|
|
|
|
|
20.
Tsai T H. Simultaneous measurement of cefuroxime in rat blood and brain by microdialysis and microbore liquid chromatography. Application to pharma-cokinetics.
J Chromatogr B,1999,735:25-31
|
被引
1
次
|
|
|
|
|
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