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单族毒素Tenuipesine A的全合成研究
Toward the total synthesis of Tenuipesine A
查看参考文献8篇
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文摘
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以1,3-环己二酮和香叶醇为起始原料,通过12步反应,合成了具有3/6/5三环骨架的关键中间体4.其中关键反应有:[3,3]重排反应一步构筑两个相邻的全碳季碳中心;Grubbs-2nd催化剂催化的关环复分解反应构筑5元环;Simmons-Smith环丙烷化反应构筑3元环. |
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其他语种文摘
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A key intermediate 4 with 3/6/5 tricyclic core was synthesized in 12 steps from 1, 3-cyclohexanedione and geraniol, paving the way for the total synthesis of Tenuipesine A. The developed synthetic strategy featured a [3, 3] rearrangment reaction to introduce two contiguous all-carbon quaternary centers; a ring closing metathesis reaction was catalyzed by Grubbs-2nd catalyst to form a five-membered ring; and a Simmons-Smith reaction was utilized to construct a cyclopropane moiety. |
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来源
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兰州大学学报. 自然科学版
,2012,48(5):135-138 【核心库】
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关键词
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Tenuipesine A
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全碳季碳
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关环复分解反应
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Simmons-Smith环丙烷化反应
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地址
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兰州大学化学化工学院, 功能有机分子化学国家重点实验室, 兰州, 730000
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语种
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中文 |
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ISSN
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0455-2059 |
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学科
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化学 |
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基金
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国家自然科学基金项目
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国家973计划
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卫生部国家重点科技项目“重大新药开发”项目
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兰州大学高等学校学科创新引智计划(111计划)项目
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文献收藏号
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CSCD:4663214
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参考文献 共
8
共1页
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1.
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被引
7
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2.
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被引
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被引
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5.
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被引
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