孤独症谱系障碍的遗传基础与神经机制
Genetic Basis and Neural Mechanism of Autism Spectrum Disorder
查看参考文献65篇
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文摘
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孤独症谱系障碍(autism spectrum disorder,ASD)是一种神经精神障碍,主要表现为社会交往障碍、交流障碍以及局限性的兴趣和重复刻板的行为模式三个主要核心症状.本文介绍了ASD的遗传基础和神经机制的最新研究进展.ASD具有较高的遗传率,且ASD个体的5-羟色胺和睾丸激素都较高.神经影像学研究发现,ASD个体的杏仁核、扣带回、梭状回、镜像神经元和前额叶等大脑区域在结构和功能上都与正常发育个体存在差异,但在个别区域激活模式的差异方向上仍存在不一致的地方.此外,功能连接的研究结果也证实了ASD个体连接不良的假设.未来的研究应该更多地着眼于如何利用这些基础研究成果为临床上提出有效的治疗和训练方式. |
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其他语种文摘
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Autism spectrum disorder(ASD) is a defective mental disease and its core impairments are social function defect,communication defect,restrictive and stereotyped behavior pattern.The paper introduces the genetic basis and neural mechanism of ASD.ASD has high genetic rate,and 5-HT and testosterone of ASD individual are both higher.Neuroimaging studies find that there are some differences between ASD and normal individuals in the structure and function of amygdala,cingulate gyrus,the fusiform gyrus,mirror neurons,prefrontal lobe and other brain areas,but it is inconsistent in the discrepancy direction of some areas’ activation patterns.In addition,the results of functional connectivity studies also confirm the hypothesis that the ASD individuals are under-connection.Future research should focus more on how to use the basic research outcomes to put forward effective treatment and training for clinical research. |
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来源
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生物化学与生物物理进展
,2012,39(10):952-961 【核心库】
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DOI
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10.3724/sp.j.1206.2011.00519
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关键词
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孤独症谱系障碍
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基因
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脑功能
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脑功能连接
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地址
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中国科学院心理研究所, 中国科学院行为科学重点实验室, 北京, 100101
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语种
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中文 |
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ISSN
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1000-3282 |
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学科
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社会科学总论 |
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基金
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国家973计划
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国家自然科学基金资助项目
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文献收藏号
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CSCD:4652428
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参考文献 共
65
共4页
|
|
1.
刘静. 儿童孤独症谱系障碍早期发现的研究进展.
实用儿科临床杂志,2010,25(23):1775-1777
|
被引
7
次
|
|
|
|
|
2.
Association Psychiatric Association.
Diagnostic and statistical manual of mental disorders: DSM-IV-TR,2000
|
被引
2
次
|
|
|
|
|
3.
Freeth M. Do gaze cues in complex scenes capture and direct the attention of high functioning adolescents with ASD? Evidence from eye-tracking.
J Autism and Developmental Disorders,2010,40(5):534-547
|
被引
5
次
|
|
|
|
|
4.
Sullivan M. Response to joint attention in toddlers at risk for autism spectrum disorder: a prospective study.
J Autism and Developmental Disorders,2007,37(1):37-48
|
被引
8
次
|
|
|
|
|
5.
Deruelle C. Spatial frequency and face processing in children with autism and Asperger syndrome.
J Autism and Developmental Disorders,2004,34(2):199-210
|
被引
5
次
|
|
|
|
|
6.
Colombi C. Examining correlates of cooperation in autism.
Autism,2009,13(2):143
|
被引
2
次
|
|
|
|
|
7.
Dawson G. Social brain circuitry in autism.
Human Behavior and The Developing Brain. (2nd),2007:28-55
|
被引
1
次
|
|
|
|
|
8.
Moran J M. Impaired theory of mind for moral judgment in high-functioning autism.
Proc Natl Acad Sci USA,2011,108(7):2688-2692
|
被引
9
次
|
|
|
|
|
9.
Yoshida W. Cooperation and heterogeneity of the autistic mind.
J Neurosci,2010,30(26):8815-8818
|
被引
3
次
|
|
|
|
|
10.
Liebal K. Helping and cooperation in children with autism.
J Autism and Developmental Disorders,2008,38(2):224-238
|
被引
4
次
|
|
|
|
|
11.
Kasari C. Focused and social attention of autistic children in interactions with familiar and unfamiliar adults: A comparison of autistic, mentally retarded, and normal children.
Development and Psychopathology,1993,5(3):403-403
|
被引
2
次
|
|
|
|
|
12.
Carpenter M. Understanding of others' intentions in children with autism.
J Autism and Developmental Disorders,2001,31(6):589-599
|
被引
2
次
|
|
|
|
|
13.
Parks L K. Neural correlates of communication skill and symptom severity in autism: A voxel-based morphometry study.
Research in Autism Spectrum Disorders,2009,3(2):444-454
|
被引
1
次
|
|
|
|
|
14.
Sumiyoshi C. Impaired ability to organize information in individuals with autism spectrum disorders and their siblings.
Neurosci Res,2011,69(3):252-257
|
被引
1
次
|
|
|
|
|
15.
Liss M. Executive functioning in highfunctioning children with autism.
J Child Psychol Psyc,2001,42(02):261-270
|
被引
3
次
|
|
|
|
|
16.
Piggot J. Neural systems approaches to the neurogenetics of autism spectrum disorders.
Neuroscience,2009,164(1):247-256
|
被引
2
次
|
|
|
|
|
17.
Allen-Brady K. A high-density SNP genome-wide linkage scan in a large autism extended pedigree.
Mol Psychiatry,2009,14(6):590-600
|
被引
2
次
|
|
|
|
|
18.
Wassink T H. Posterior probability of linkage analysis of autism dataset identifies linkage to chromosome 16.
Psychiatric Genetics,2008,18(2):85
|
被引
1
次
|
|
|
|
|
19.
Anderson B. Examination of association of genes in the serotonin system to autism.
Neurogenetics,2009,10(3):209-216
|
被引
2
次
|
|
|
|
|
20.
Cowan W M. The human genome project and its impact on psychiatry.
Annu Rev Neurosci,2002,25(1):1-50
|
被引
2
次
|
|
|
|
|
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