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Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia

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Tian Guoping 1 *   Zhou Jin 1   Jinge Wang 1   Xu Bing 1   Li Li 1   Zhu Feng 1   Han Jian 1   Li Jianping 2   Zhang Siyang 3   Luo Xiaoguang 4  
文摘 OBJECTIVE:To review published data on the biological characteristics,differentiation and applications of adipose-derived stem cells in ischemic diseases.DATA RETRIEVAL:A computer-based online search of reports published from January 2005 to June 2012 related to the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia was performed in Web of Science using the key words "adipose-derived stem cells","neural-like cells","transplantation","stroke",and "cerebral ischemia".SELECTION CRITERIA:The documents associated with the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia were selected,and those published in the last 3-5 years or in authoritative journals were preferred in the same field.Totally 89 articles were obtained in the initial retrieval,of which 53 were chosen based on the inclusion criteria.MAIN OUTCOME MEASURES:Biological characteristics and induced differentiation of adipose-derived stem cells and cell transplantation for disease treatment as well as the underlying mechanism of clinical application.RESULTS:The advantages of adipose-derived stem cells include their ease of procurement,wide availability,rapid expansion,low tumorigenesis,low immunogenicity,and absence of ethical constraints.Preclinical experiments have demonstrated that transplanted adipose-derived stem cells can improve neurological functions,reduce small regions of cerebral infarction,promote angiogenesis,and express neuron-specific markers.The improvement of neurological functions was demonstrated in experiments using different methods and time courses of adipose-derived stem cell transplantation,but the mechanisms remain unclear.CONCLUSION:Further research into the treatment of ischemic disease by adipose-derived stem cell transplantation is needed to determine their mechanism of action.
来源 Neural Regeneration Research ,2012,7(25):1992-1999 【核心库】
DOI 10.3969/j.issn.1673-5374.2012.25.011
关键词 adipose-derived stem cells ; adipose stem cells ; differentiation ; adipose tissue ; neural-like cells ; transplantation ; stroke ; cerebral ischemia ; cerebrovascular disease ; stem cell therapy
地址

1. Department of Neurology,Shenyang First People’s Hospital, Liaoning, Shenyang, 110041  

2. Liaoning Blood Center, Liaoning, Shenyang, 110044  

3. College of Basic Medical Science,China Medical University, Liaoning, Shenyang, 110001  

4. Department of Neurology,First Affiliated Hospital of China Medical University, Liaoning, Shenyang, 110001

语种 英文
ISSN 1673-5374
学科 神经病学与精神病学
基金 supported by the Research Foundation of Shenyang Scientific Committee
文献收藏号 CSCD:4648170

参考文献 共 56 共3页

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引证文献 2

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