Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats
查看参考文献27篇
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文摘
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Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly.To establish a hyperhomocysteinemic pregnant rat model,2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of gestation.Folic acid was administered by intragastric administration at a dose of 20 mg/kg during the period of preeclampsia induction.Results showed that systolic blood pressure,proteinuria/creatinine ratio,and plasma homocysteine levels in the hyperhomocys-teinemic pregnant rats increased significantly,and that body weight and brain weight of rat pups significantly decreased.Folic acid supplementation markedly reversed the above-mentioned abnormal changes of hyperhomocysteinemic pregnant rats and rat pups.These findings suggest that folic acid can alleviate the symptoms of hyperhomocysteinemia-induced preeclampsia in pregnant rats without influencing brain development of rat pups. |
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来源
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Neural Regeneration Research
,2012,7(25):1954-1959 【核心库】
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DOI
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10.3969/j.issn.1673-5374.2012.25.005
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关键词
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folic acid
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preeclampsia
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hyperhomocysteinemia
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proteinuria
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creatinine
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preeclampsia-like symptom
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pregnant rats
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offspring
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brain
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nervous system
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regeneration
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neural regeneration
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地址
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1.
Department of Gynaecology and Obstetrics,the 202 Hospital of People’s Liberation Army, Liaoning, Shenyang, 110003
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Department of Emergency Medicine,General Hospital of Shenyang Military Region, Liaoning, Shenyang, 110016
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Department of Gynaecology and Obstetrics,the Second People’s Hospital of Tongliao, Inner Mongolia, Tongliao, 280000
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语种
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英文 |
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ISSN
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1673-5374 |
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学科
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妇产科学 |
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基金
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The Medical Science and Technology Foundation of Chinese PLA during Twelfth “Five-year” Development Period(General Program)
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文献收藏号
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CSCD:4648164
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