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Gene expression microarray analysis of the spinal trigeminal nucleus in a rat model of migraine with aura

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文摘 Cortical spreading depression can trigger migraine with aura and activate the trigeminal vascular system. To examine gene expression profiles in the spinal trigeminal nucleus in rats following cor-tical spreading depression-induced migraine with aura, a rat model was established by injection of 1 M potassium chloride, which induced cortical spreading depression. DNA microarray analysis re-vealed that, compared with the control group, the cortical spreading depression group showed seven upregulated genes-myosin heavy chain 1/2, myosin light chain 1, myosin light chain (phos-phorylatable, fast skeletal muscle), actin alpha 1, homeobox B8, carbonic anhydrase 3 and an un-known gene. Two genes were downregulated-RGD1563441 and an unknown gene. Real-time quantitative reverse transcription-PCR and bioinformatics analysis indicated that these genes are involved in motility, cell migration, CO2/nitric oxide homeostasis and signal transduction.
来源 Neural Regeneration Research ,2012,7(25):1931-1938 【核心库】
DOI 10.3969/j.issn.1673-5374.2012.25.002
关键词 migraine with aura ; cortical spreading depression ; spinal nucleus of trigeminal nerve ; nervous sys-tem ; potassium chloride ; gene expression ; cell migration ; ubiquitin degradation ; enzyme ; regenera-tion ; neural regeneration
地址

1. Department of Neurology, Chinese PLA General Hospital, Beijing, 100853  

2. Department of Neurology, General Hospital of Shenyang Military Region, Shenyang, 110016  

3. Department of Neurology, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing, 100037

语种 英文
ISSN 1673-5374
学科 神经病学与精神病学
基金 supported by the General Program ofthe National Natural Science Foundation of China
文献收藏号 CSCD:4648161

参考文献 共 37 共2页

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引证文献 1 篇

1 He Yifan Age-dependent loss of cholinergic neurons in learning and memory-related brain regions and impaired learning in SAMP8 mice with trigeminal nerve damage Neural Regeneration Research,2014,9(22):1985-1994
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