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Design,synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety

Zhang Bei ¹ Zhao Yan Fang ¹ Zhai Xin ¹ Fan Wei Jie ¹ Ren Jun Ling ¹ Wu Chun Fu ² Gong Ping ¹ ^*

文摘	A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized.All the target compounds were evaluated for their antiproliferative activities against human leukemia cell line(HL-60),human lung adenocarcinoma epithelial cell line(A549) and human breast cancer cell line(MDA-MB-231) in vitro by standard MTT assay.The pharmacological results indicated that some compounds exhibited promising antitumor activities.Compound 1j showed the most potent antiproliferative activity against the tested three cell lines with IC values of 0.13 mmol/L,0.7 mmol/L and 0.5 mmol/L,respectively.
来源	Chinese Chemical Letters ,2012,23(8):915-918 【核心库】
DOI	10.1016/j.cclet.2012.06.009
关键词	Diaryl ureas ; N-acylhydrazone ; Antiproliferative activities
地址	1. School of Pharmaceutical Engineering,Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design & Discovery,Ministry of Education, Shenyang, 110016 2. School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University, Shenyang, 110016
语种	英文
ISSN	1001-8417
学科	化学
基金	Shenyang Scienceand Technology Plan Projects ; 国家自然科学基金 ; pported by the National High Technology Research and Development Program ("863"rogram)of China
文献收藏号	CSCD:4601190

参考文献共 11 共1页

引证文献 2 篇

1 Lv Xiashi Synthesis and BK channel-opening activity of novel N-acylhydrazone derivatives from dehydroabietic acid Chinese Chemical Letters,2013,24(11):1023-1026
被引 3 次

2 高霞两种新型苯甲酰腙配合物的合成及其结构和抑菌活性研究陕西师范大学学报. 自然科学版,2020,48(5):11-18
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