帮助 关于我们

返回检索结果

细菌必需基因、最小基因组和合成细胞
Essential genes,minimal genome and synthetic cell of bacteria:a review

查看参考文献35篇

邱东茹 *  
文摘 单细胞原核生物是原始的细胞生命形式,确定细菌必需基因和最小基因组对理解生命的本质、细胞生命的起源和进化有非常重要的意义。文中简要介绍近年来有关细菌的必需基因、最小基因组和合成细胞的研究方法、理论和进展。还特别介绍人工建立最小细菌基因组的策略以及应用前景。
其他语种文摘 Single-cell prokaryotes represent a simple and primitive cellular life form.The identification of the essential genes of bacteria and the minimal genome for the free-living cellular life could provide insights into the origin,evolution,and essence of life forms.The principles,methodology,and recent progresses in the identification of essential genes and minimal genome and the creation of synthetic cells are reviewed and particularly the strategies for creating the minimal genome and the potential applications are introduced.
来源 生物工程学报 ,2012,28(5):540-549 【核心库】
关键词 必需基因 ; 最小基因组 ; 合成细胞 ; 虚拟细胞
地址

中国科学院水生生物研究所, 湖北, 武汉, 430072

语种 中文
文献类型 研究性论文
ISSN 1000-3061
学科 生物工程学(生物技术)
基金 中国科学院知识创新工程项目
文献收藏号 CSCD:4535736

参考文献 共 35 共2页

1.  Schrodinger E. What Is Life? The Physical Aspect of the Living Cell. 1st ed,1944:1-92 被引 1    
2.  Perez-Brocal V. A small microbial genome: the end of a long symbiotic relationship?. Science,2006,314(5797):312-313 被引 5    
3.  Nakabachi A. The 160-kilobase genome of the bacterial endosymbiont Carsonella. Science,2006,314(5797):267 被引 12    
4.  Andersson S G E. The bacterial world gets smaller. Science,2006,314(5797):259-260 被引 1    
5.  Mushegian A R. A minimal gene set for cellular life derived by comparison of complete bacterial genomes. Proc Natl Acad Sci USA,1996,93(19):10268-10273 被引 17    
6.  Koonin E V. How many genes can make a cell: the minimal-gene-set concept. Annu Rev Genomics Hum Genet,2000,1(1):99-116 被引 7    
7.  Koonin E V. Comparative genomics, minimal gene-sets and the last universal common ancestor. Nature Rev Microbiol,2003,1(2):127-136 被引 9    
8.  Gil R. Determination of the core of a minimal bacterial gene set. Microbiol Mol Biol Rev,2004,68(3):518-537 被引 8    
9.  Itaya M. An estimation of minimal genome size required for life. FEBS Lett,1995,362(3):257-260 被引 4    
10.  Hutchison C A. Global transposon mutagenesis and a minimal Mycoplasma genome. Science,1999,286(5447):2165-2169 被引 16    
11.  Fraser C M. The minimal gene complement of Mycoplasma genitalium. Science,1995,270(5235):397-404 被引 33    
12.  Judson N. TnAraOut, a transposon-based approach to identify and characterize essential bacterial genes. Nat Biotechnol,2000,18(7):740-745 被引 5    
13.  Akerley B J. A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae. Proc Natl Acad Sci USA,2002,99(2):966-971 被引 7    
14.  Forsyth R A. A genome-wide strategy for the identification of essential genes in Staphylococcus aureus. Mol Microbiol,2002,43(6):1387-1400 被引 11    
15.  Kobayashi K. Essential Bacillus subtilis genes. Proc Natl Acad Sci USA,2003,100(8):4678-4683 被引 20    
16.  Westers H. Genome engineering reveals large dispensable regions in Bacillus subtilis. Mol Biol Evol,2003,20(12):2076-2090 被引 19    
17.  Yu B J. Minimization of the Escherichia coli genome using a Tn 5-targeted Cre/loxP excision system. Nat Biotechnol,2002,20(10):1018-1023 被引 10    
18.  Kolisnychenko V. Engineering a reduced Escherichia coli genome. Genome Res,2002,12(4):640-647 被引 23    
19.  Goryshin I Y. Chromosomal deletion formation system based on Tn5 double transposition: use for making minimal genomes and essential gene analysis. Genome Res,2003,13(4):644-653 被引 7    
20.  Posfai G. Emergent properties of reduced-genome Escherichia coli. Science,2006,312(5776):1044-1046 被引 33    
引证文献 3

1 左丽媛 Latour system精简酿酒酵母染色体方法的建立及应用 微生物学杂志,2015,35(2):9-13
被引 0 次

2 汤彬彩 一种基于代谢网络分析最小化基因组的方法及其在大肠杆菌中的应用 生物工程学报,2013,29(8):1173-1184
被引 1

显示所有3篇文献

论文科学数据集
PlumX Metrics
相关文献

 作者相关
 关键词相关
 参考文献相关

版权所有 ©2008 中国科学院文献情报中心 制作维护:中国科学院文献情报中心
地址:北京中关村北四环西路33号 邮政编码:100190 联系电话:(010)82627496 E-mail:cscd@mail.las.ac.cn 京ICP备05002861号-4 | 京公网安备11010802043238号