氧化应激对骨髓间充质干细胞的影响
Effect of Oxidative Stress on Bone Marrow Mesenchymal Stem Cells
查看参考文献27篇
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文摘
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骨髓间充质干细胞(MSCs)是一种成体干细胞,它具有多向分化的能力及免疫调节特性,对维持正常的造血功能及应用于干细胞治疗方面意义重大。氧化应激是指因活性氧增多而引起的机体氧化还原水平失调的状态。氧化应激是影响骨髓MSCs生存的重要因素之一,它可通过磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/AKT)、p53等途径诱导MSCs的衰老及凋亡,通过脱嘌呤/脱嘧啶核酸内切酶/氧化还原因子-1(APE/REF-1)、细胞外信号调节蛋白激酶(ERK)途径抑制MSCs的增殖及分化;抗氧化应激预处理可增强MSCs的功能。研究氧化应激对MSCs的影响、相关信号转导通路以及如何增强骨髓MSCs的抗氧化应激能力,对更好地治疗造血系统疾病及利用MSCs的再生修复功能进行细胞治疗具有重要意义。 |
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其他语种文摘
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Bone marrow mesenchymal stem cells(MSCs) are somatic stem cells that can differentiate into progenies of multiple lineages.They play an important role in hematopoiesis and stem cell therapy due to their multi-lineage potentials and immunomodulatory properties.Oxidative stress is a disturbed redox state caused by accumulation of reactive oxygen species.It can induce the senescence and apoptosis of MSCs via phosphatidylinositol 3-kinase/protein kinase B(PI3K/AKT) and p53 pathways,and inhibit the proliferation and differentiation of MSCs through apurinic/apyrimidinic endonuclease/redox factor 1(APE/REF-1) and extracellular signal-regulated kinase(ERK) pathways.Furthermore,using anti-stress medication and hypoxic preconditioning,the functions of MSCs can be further enhanced.Accordingly,further studies on the effect of oxidative stress on MSCs and its signaling pathways may be meaningful for the treatment of hematologic diseases and for improving stem cell therapy. |
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来源
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中国医学科学院学报
,2012,34(1):90-94 【核心库】
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DOI
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10.3881/j.issn.1000-503x.2012.01.017
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关键词
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氧化应激
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间充质干细胞
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骨髓
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信号传导
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地址
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天津医科大学一中心临床学院,天津市第一中心医院血液科, 天津, 300192
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1000-503X |
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学科
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内科学 |
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基金
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国家自然科学基金
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国家教育部留学回国人员科研启动基金
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文献收藏号
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CSCD:4476934
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