深部脑刺激治疗疼痛的基础研究与临床应用进展
查看参考文献19篇
文摘
|
深部脑刺激(Deep Brain Stimulation,DBS)是一种广泛用于治疗中枢神经及精神疾病的功能型手术疗法,其用于镇痛的历史可以追溯到半个多世纪以前。临床实践证实,DBS能够有效缓解多种顽固性疼痛,包括神经损伤性痛、患肢痛、丛集性头痛以及因手术治疗失败而致的腰背痛等,总体有效率约为50%到60%,部分高达80%。虽然其适应症、刺激部位及参数选择都存在一定争议,产生镇痛作用的神经机制也不完全清楚,导致其临床应用存在局限性,但对于那些各类镇痛药物都无法控制或患者自身无法承受药物副作用的顽固性疼痛,选择DBS能够有效帮助患者摆脱疼痛困扰,改善生活质量,因此不失为一种好的替代选择。本文将围绕DBS镇痛的基础研究及其临床应用情况进行概括性介绍,旨在为临床应用提供更加完备的理论支持。 |
来源
|
中国疼痛医学杂志
,2011,17(12):752-756 【扩展库】
|
关键词
|
基础研究
;
镇痛效果
;
镇痛作用
;
深部脑刺激
;
手术疗法
;
顽固性疼痛
;
神经损伤
;
下丘脑
;
电生理研究
;
治疗效果
|
地址
|
中国科学院心理研究所, 中国科学院心理健康院重点实验室, 北京, 100101
|
语种
|
中文 |
文献类型
|
综述型 |
ISSN
|
1006-9852 |
学科
|
临床医学 |
文献收藏号
|
CSCD:4400102
|
参考文献 共
19
共1页
|
1.
Fardin V. A reinvestigation of the analgesic effects induced by stimulation of the periaqueductal gray matter in the rat. I. The production of behavioral side effects together with analgesia.
Brain Res,1984,306:105-123
|
被引
1
次
|
|
|
|
2.
Leith J L. Spinal processing of noxious and innocuous cold information: differential modulation by the periaqueductal gray.
J Neurosci,2010,30:4933-4942
|
被引
2
次
|
|
|
|
3.
Amano K. Alterations of immunoreactive beta-endorphin in the third ventricular fl uid in response to electrical stimulation of the human periaqueductal gray matter.
Appl Neurophysiol,1980,43:150-158
|
被引
1
次
|
|
|
|
4.
Akil H. Monoaminergic mechanisms of stimulation-produced analgesia.
Brain Res,1975,94:279-296
|
被引
4
次
|
|
|
|
5.
Guinan M J. Electrical stimulation of the rat ventral midbrain elicits antinociception via the dorsolateral funiculus.
Brain Res,1989,485:333-348
|
被引
1
次
|
|
|
|
6.
Nandi D. Thalamic field potentials in chronic central pain treated by periventricular gray stimulation -- a series of eight cases.
Pain,2003,101:97-107
|
被引
2
次
|
|
|
|
7.
Mazars G J. Intermittent stimulation of nucleus ventralis posterolateralis for intractable pain.
Surg Neurol,1975,4:93-95
|
被引
2
次
|
|
|
|
8.
Rezai A R. Thalamic stimulation and functional magnetic resonance imaging: localization of cortical and subcortical activation with implanted electrodes.Technical note.
J Neurosurg,1999,90:583-590
|
被引
3
次
|
|
|
|
9.
Davis K D. Activation of the anterior cingulate cortex by thalamic stimulation in patients with chronic pain: a positron emission tomography study.
J Neurosurg,2000,92:64-69
|
被引
4
次
|
|
|
|
10.
Kung J C. Potentiation of local fi eld potentials in the anterior cingulate cortex evoked by the stimulation of the medial thalamic nuclei in rats.
Brain Res,2002,953:37-44
|
被引
3
次
|
|
|
|
11.
Gerhart K D. Inhibition of primate spinothalamic tract neurons by stimulation in ventral posterior lateral (VPLc) thalamic nucleus: possible mechanisms.
J Neurophysiol,1983,49:406-423
|
被引
3
次
|
|
|
|
12.
Yamamoto T. Thalamic sensory relay nucleus stimulation for the treatment of peripheral deafferentation pain.
Stereotact Funct Neurosurg,2006,84:180-183
|
被引
2
次
|
|
|
|
13.
Tang J S. The thalamic nucleus submedius and ventrolateral orbital cortex are involved in nociceptive modulation: a novel pain modulation pathway.
Prog Neurobiol,2009,89:383-389
|
被引
7
次
|
|
|
|
14.
Stadler J A 3rd. Deep brain stimulation and motor cortical stimulation for neuropathic pain.
Curr Pain Headache Rep,2011,15:8-13
|
被引
4
次
|
|
|
|
15.
Bittar R G. Deep brain stimulation for pain relief: a metaanalysis.
J Clin Neurosci,2005,12:515-519
|
被引
9
次
|
|
|
|
16.
Levy R. Intracranial neurostimulation for pain control: a review.
Pain Physician,2010,13:157-165
|
被引
4
次
|
|
|
|
17.
Owen S L. Deep brain stimulation for neuropathic pain.
Acta Neurochir Suppl,2007,97:111-116
|
被引
4
次
|
|
|
|
18.
Fontaine D. Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension.
J Headache Pain,2009,11:23-31
|
被引
1
次
|
|
|
|
19.
Pickering A E. Analgesia in conjunction with normalisation of thermal sensation following deep brain stimulation for central post-stroke pain.
Pain,2009,147:299-304
|
被引
1
次
|
|
|
|
|