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深部脑刺激治疗疼痛的基础研究与临床应用进展

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文摘 深部脑刺激(Deep Brain Stimulation,DBS)是一种广泛用于治疗中枢神经及精神疾病的功能型手术疗法,其用于镇痛的历史可以追溯到半个多世纪以前。临床实践证实,DBS能够有效缓解多种顽固性疼痛,包括神经损伤性痛、患肢痛、丛集性头痛以及因手术治疗失败而致的腰背痛等,总体有效率约为50%到60%,部分高达80%。虽然其适应症、刺激部位及参数选择都存在一定争议,产生镇痛作用的神经机制也不完全清楚,导致其临床应用存在局限性,但对于那些各类镇痛药物都无法控制或患者自身无法承受药物副作用的顽固性疼痛,选择DBS能够有效帮助患者摆脱疼痛困扰,改善生活质量,因此不失为一种好的替代选择。本文将围绕DBS镇痛的基础研究及其临床应用情况进行概括性介绍,旨在为临床应用提供更加完备的理论支持。
来源 中国疼痛医学杂志 ,2011,17(12):752-756 【扩展库】
关键词 基础研究 ; 镇痛效果 ; 镇痛作用 ; 深部脑刺激 ; 手术疗法 ; 顽固性疼痛 ; 神经损伤 ; 下丘脑 ; 电生理研究 ; 治疗效果
地址

中国科学院心理研究所, 中国科学院心理健康院重点实验室, 北京, 100101

语种 中文
文献类型 综述型
ISSN 1006-9852
学科 临床医学
文献收藏号 CSCD:4400102

参考文献 共 19 共1页

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引证文献 2

1 魏乃礼 神经毁损术与神经调制术治疗中枢性疼痛的研究进展 中国疼痛医学杂志,2013,19(10):614-617
被引 1

2 温志娟 脑卒中后中枢神经痛的诊疗进展 中国疼痛医学杂志,2014,20(12):892-895
被引 2

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