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Design, Synthesis and Antifungal Activity of 6-Fluoro-3, 3a, 4, 5-tetrahydro-2H-pyrazolo [4, 3-c]-quinoline-2-carboxamide Derivatives

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文摘 A series of 6-fluoro-3, 3a, 4, 5-tetrahydro-2H-pyrazolo[4, 3-c]quinoline-2-carboxanide derivatives was designed based on the bioisosterism and combination principle in drug design. The target compounds were synthesized from substituted aniline through Michael addition, cyclization, Mannich reaction and condensation with 4-substituted semicarbazides, and the structures were confirmed by mass spectrometry(MS) and 'H NMR. The antifungal assay was carried out in vitro by two-fold dilution. The result shows that all the compounds are of antifungal activities against the tested fungi at different levels.
来源 Chemical Research in Chinese Universities ,2011,27(6):955-957 【核心库】
关键词 6-Fluoro-3, 3a, 4, 5-tetrahydro-2H-pyrazolo[4, 3-c]quinoline-2-carboxamide derivative ; Cysteine protease inhibitor ; Antifungal activity Article ID 1005-9040(2011)-06-955-03
地址

Shenyang Pharmaceutical University, Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang, 110016

语种 英文
文献类型 研究性论文
ISSN 1005-9040
学科 化学
基金 Supported by the National Science and Technology Major Projects of China
文献收藏号 CSCD:4377190

参考文献 共 20 共1页

1.  Decory T R. Eur. J. Med. Chem,1989,24:563 被引 1    
2.  Lamb D C. Pestic Sci,1996,46:294 被引 1    
3.  Haller M A. Antimicrob. Agents Chemother,1994,43:169 被引 1    
4.  Elizabeth A S. Clin. Ther,2002,24:351 被引 16    
5.  Ji H. J. Med. Chem,2003,46:47 被引 1    
6.  Frank C O. Trends in Microbiology,2003,11:272 被引 2    
7.  Wan J. Synthesis, Structure and Biological Activities of 2-(1H- 1,2,3-Benzotriazol-1 -yl )-1-( 4- methylphenyl )-2-(1H-1,2,4-triazol-l-yl)-1-ethanone. Chem. Res. Chinese Universities,2006,22(4):465 被引 2    
8.  Xu L Z. Syntheses and Biological Activities of Novel Benzotriazole Compounds Containing a Thioamide Group. Chem. Res. Chinese Universities,2006,22(5):574 被引 1    
9.  Kiran S. Synth. React. Inorg. Met. Org. Chem,1987,3:385 被引 1    
10.  Margolin N. Biol. Chem,1997,272:7223 被引 1    
11.  Thornberry N A. Biol. Chem,1997,272:17901 被引 1    
12.  Liu Y. Drug Discov. Ther,2008,2:216 被引 1    
13.  Qi P. Chin. J. Chem,2003,13:134 被引 1    
14.  Alex C. Biol & Med. Chem,2007,15:273 被引 1    
15.  Tan C X. Chin J. Org. Chem,2008,28:1836 被引 1    
16.  Ferrarini P L. Eur. J. Med. Chem,2000,35:815 被引 4    
17.  Zhu Q H. Chin. J. Med. Chem,2000,10:5 被引 1    
18.  Huo N. Organic Chemistry,1981:499 被引 1    
19.  Chen H T. Acta Pharmaceutica Sinica,1991,26:183 被引 4    
20.  Gao F. Chin. J. Applied Chem,2004,21:374 被引 1    
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