帮助 关于我们

返回检索结果

唐古特白刺红色素毒理学安全性评价
Safety Assessment of Nitraria tangutorum Bobr. Pigment

查看参考文献5篇

文摘 目的对唐古特白刺红色素毒理学安全性进行评价。方法清洁级昆明种小鼠、SD大鼠以唐古特白刺红色素各按最大耐受量(MTD)等体积灌胃,记录中毒表现及死亡情况;采用平板掺入法;分加与不加S-9混合液两种;选清洁级昆明种小鼠,取胸骨骨髓制片;检查骨髓嗜多染红细胞微核发生率;选雄性小鼠;取附睾制片;查小鼠精子畸形率;90 d喂养实验,观察生长发育、食物利用率、血液学检查、生化检查和组织病理检测结。结果雌雄性小、大鼠均未见明显的中毒症状及死亡;在加与不加S-9的情况下,均未呈现致突变作用;小鼠微核实验、小鼠精子畸形实验均呈阴性;90 d喂养大鼠,全部存活,且发育良好,选定各指标均未见异常。结论唐古特白刺红色素对两种性别的大、小鼠的MTD均大于30 000 mg/(kg?bw),说明该产品属实际无毒物;三项致突变实验结果阴性;大鼠90d喂养实验各项指标均无明显异常。
其他语种文摘 Objective To assess the safety of Nitraria tangutorum Bobr. pigment. Methods The experimental animals were Kun ming mice and SD rats. Mice and rats were gastrically infused with the same volume of Mitrarica tangutirum Bobr. pigment MTD. Toxicity and death status were recorded. Flat plate incorporating method was used with 2 kinds of mixture solutions which were added S - 9 or not. The sternal bone marrow of clean Kunming mice was isolated and fixed and the living rate of mouse bone marrow polychromatic erythrocyte micronucleus test was checked. The epididymis of the double sides in female clean Kunming mice was cut into slices and the rate of sperm teratogenicity was observed. The growth and development, food utilization rate, the changes of blood and biochemistry were obseved after the animals were fed for 30 days. Results No obvious poisoned symptom and death were observed. Without adding S - 9 condition, the mutation effect of all the animals didnt appear. The micronucleus test and the sperm teratogenicity test in mice were negative. All rats survived after feeding for 90 days. Animal growth in each group was good, and no abnormal phenomenon was observed. Conclusion The MTD of Nitraria tangutorum Bobr. pigment mice and rats is greater than 30 000 mg/ (kg. bw). It is concluded that the product has no toxicity. The result of mutagenic test is negative and no abnormal phenomenon is observed after feeding for 90 days.
来源 时珍国医国药 ,2011,22(10):2426-2428 【扩展库】
关键词 唐古特白刺红色素 ; 安全性评价
地址

中国科学院西北高原生物研究所, 青海, 西宁, 810008

语种 中文
文献类型 研究性论文
ISSN 1008-0805
学科 中国医学
基金 国家科技支撑计划项目
文献收藏号 CSCD:4362191

参考文献 共 5 共1页

1.  蒋福祯. 柴达木盆地野生白刺资源调查及其综合利用. 青海科技,2005,1:15 被引 1    
2.  张凤枰. 青藏高原白刺、枸杞和沙棘果粉中水溶性维生素含量比较分析. 食品科学,2010,31(2):179 被引 6    
3.  朱利娜. 唐古特白刺果粉的抗氧化作用研究. 中国野生植物资源,2010,29(2):41 被引 3    
4.  杜鹃. 玫瑰花中黄酮类色素的提取工艺研究. 新疆农业职业技术学院学报,2007,4:30 被引 1    
5.  孟红梅. 唐古特白刺果实红色素稳定性研究. 食品科学,2006,27(8):72 被引 8    
引证文献 2

1 杨秀艳 我国白刺植物资源及其开发利用 世界林业研究,2013,26(5):64-68
被引 9

2 蒋思绒 唐古特白刺果实酚酸类化学成分及α-葡萄糖苷酶抑制活性研究 中草药,2023,54(6):1719-1727
被引 0 次

显示所有2篇文献

论文科学数据集
PlumX Metrics
相关文献

 作者相关
 关键词相关
 参考文献相关

版权所有 ©2008 中国科学院文献情报中心 制作维护:中国科学院文献情报中心
地址:北京中关村北四环西路33号 邮政编码:100190 联系电话:(010)82627496 E-mail:cscd@mail.las.ac.cn 京ICP备05002861号-4 | 京公网安备11010802043238号