Organocatalytically Enantioselective Approach to Polysubstituted Tetrahydropyridines and Piperidines
查看参考文献19篇
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文摘
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A convenient and highly enantioselective method for assembly of functionalized 1,2,3,4,5-pentasubstituted tetrahydropyridines and piperidines was developed. This method relies on preparing the required enantiopure cyclic semi-acetals via an organocatalyzed Michael addition/cyclization cascade reaction of aldehydes and α-keto-α,β-unsaturated esters, and subsequent reductive amination/condensation with primary amines. |
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来源
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Chinese Journal of Chemistry
,2011,29(9):1873-1879 【核心库】
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DOI
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10.1002/cjoc.201180327
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关键词
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organocatalysis
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Michael addition
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reductive amination
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substituted piperidine
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tetrahydropyridine
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地址
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1.
Shenyang Pharmaceutical University, Liaoning, Shenyang, 110016
2.
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai, 200032
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1001-604X |
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学科
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化学 |
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基金
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国家自然科学基金
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文献收藏号
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CSCD:4352577
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