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Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats

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文摘 Aim: To investigate the synergism of low-doses of amlodipine and irbesartan on reduction of blood pressure variability (BPV), amelioration of baroreflex sensitivity (BRS) and organ protection in spontaneously hypertensive rats (SHR). Methods: The rats were administered amlodipine (1 mg·kg-1·d-1) alone, irbesartan (10 mg·kg-1d-') alone, or the combination of the two drugs for 4 months. The drugs were mixed into the rat chow. Blood pressure (BP) was continuously monitored in conscious animals. After the determination of BRS, the rats were killed for morphological evaluation of organ damages. Results: The combination of low-dose irbesartan and amlodipine had statistically significant synergism on reduction of BP and BPV, amelioration of BRS and organ protection in SHR. Multiple regression analysis showed that the decrease in left ventricular hypertrophy was associated with the decrease in systolic BPV (r=0.665, P<0.01); the decrease in aortic hypertrophy was associated with the increase in BRS (r=0.656, P<0.01); and the amelioration in renal lesion was associated with the increase in BRS (r=0.763, P<0.01) and the decrease in systolic BPV (r=0.706, P<0.01). Conclusion: Long-term treatment with a combination of low-doses of amlodipine and irbesartan showed significant synergism on reduction of BP and BPV, restoration of BRS and organ protection in SHR. Besides BP reduction, the enhancement of BRS and reduction of BPV might contribute to the organ protection.
来源 Acta Pharmacologica Sinica ,2011,32(9):1109-1115 【核心库】
DOI 10.1038/aps.2011.88
关键词 hypertension ; spontaneously hypertensive rats (SHR) ; amlodipine ; irbesartan ; hypertension ; end organ damage ; blood pressure variability ; baroreflex sensitivity
地址

1. Department of Pharmacology, Second Military Medical University, Shanghai, 200433  

2. School of the Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016

语种 英文
文献类型 研究性论文
ISSN 1671-4083
学科 药学
基金 National Science and Tech-nology Major Project ;  国家自然科学基金
文献收藏号 CSCD:4335557

参考文献 共 37 共2页

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