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Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis

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文摘 Background Osteoclast-associated receptor (OSCAR) is a member of the newly identified leukocyte receptor complex, and has recently been described as a key molecule in osteoclastogenesis. In this study, we measured the levels of soluble osteoclast-associated receptor (sOSCAR) in the serum of rheumatoid arthritis (RA) patients and healthy controls to examine whether sOSCAR may play a role in the process of inflammatory arthritis. Methods Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of sOSCAR in the serum of 40 healthy controls and 40 RA patients. Results The serum levels of sOSCAR were significantly lower in RA patients than in healthy controls, and were inversely associated with inflammatory activity. Conclusion sOSCAR is decreased in patients with RA and reduced levels of the protein are associated with increased inflammatory response.
来源 Chinese Medical Journal ,2011,124(19):3058-3060 【核心库】
DOI 10.3760/cma.j.issn.0366-6999.2011.19.019
关键词 Osteoclast ; Osteoclast-associated receptor ; Rheumatoid arthritis
地址

Department of Rheumatism, Shengjing Hospital, China Medical University, Liaoning, Shenyang, 110004

语种 英文
文献类型 研究性论文
ISSN 0366-6999
学科 外科学
基金 国家自然科学基金
文献收藏号 CSCD:4321541

参考文献 共 7 共1页

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引证文献 2

1 Cheng Tao Tartrate-resistant acid phosphatase 5b is a potential biomarker for rheumatoid arthritis: a pilot study in Han Chinese Chinese Medical Journal,2014,127(16):2894-2899
被引 2

2 Guo Yingying Increased interleukin-23 is associated with increased disease activity in patients with rheumatoid arthritis Chinese Medical Journal,2013,126(5):850-854
被引 0 次

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