多环百部生物碱Stemonamine的全合成
An efficient total synthesis of Stemonamine
查看参考文献15篇
文摘
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以新颖的环氧醇串联Semipinacol重排/Schmidt反应为关键步骤,设计发展了高效构筑含有氮杂季碳中心的[5,5,7]三环骨架1的方法.本文从关键中间体1出发,设计了关键的酮酯缩合反应构筑D环的方法,经过7步转化,高效、高选择性地完成了蔓生百部碱Stemonamine的全合成. |
其他语种文摘
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A short and efficient approach to the Stemona alkaloids has been developed.The representative members,Stemonamine,has been synthesized from the known key intermediate 1 in 7 steps and 47.3% overall yield featured by a novel ketone-ester condensation to forge the spirolactone ring. |
来源
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中国科学. 化学
,2011,41(3):474-478 【核心库】
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关键词
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串联反应
;
全合成
;
蔓生百部碱
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地址
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兰州大学化学化工学院, 功能有机分子化学国家重点实验室, 兰州, 730000
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语种
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中文 |
文献类型
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研究性论文 |
ISSN
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1674-7224 |
学科
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化学工业 |
基金
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国家自然科学基金
;
国家教育部高等学校学科创新引智计划项目
;
国家973计划
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文献收藏号
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CSCD:4268324
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参考文献 共
15
共1页
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