康艾注射液辅助化疗对晚期非小细胞肺癌患者血清VEGF表达的干预作用
Intervention Effects of Adjuvant Chemotherapy Combined with Kangai Injection on Expression of Serum VEGF in Patients with Advanced Non-small Cell Lung Cancer
查看参考文献9篇
文摘
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目的 探讨康艾注射液辅助化疗对晚期非小细胞肺癌患者血清VEGF(sVEGF)表达的干预作用。方法 将入组的46例晚期非小细胞肺癌患者随机分为实验组(康艾注射液联合化疗组,23例)和对照组(单纯化疗组23例),应用酶联免疫吸附法(ELISA)检测患者治疗前后sVEGF表达水平,并加以比较。结果 肺癌患者sVEGF水平明显高于健康对照者(P<0.05)。鳞癌组sVEGF高于腺癌、大细胞癌和腺鳞癌组(P<0.05),而腺癌、大细胞癌和腺鳞癌组之间差异无统计学意义(P>0.05)。中低分化组sVEGF较高分化组有增高但差异无统计学意义(P>0.05)。和治疗前比较,康艾注射液联合化疗组和单纯化疗组治疗后sVEGF水平均明显降低(P<0.05)。和单纯化疗组比较,康艾注射液联合化疗组治疗后sVEGF下降更为显著(P<0.05)。结论 康艾注射液辅助化疗可降低晚期非小细胞肺癌患者血清VEGF水平,对抑制肿瘤血管形成有一定的作用。血清VEGF有望作为肿瘤标志物用于肺癌患者的诊断和化疗或生物治疗等的疗效评价。 |
其他语种文摘
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Objective To explore the effects of adjuvant chemotherapy combined with Kangai injection on the expression of serum VEGF in patients with advanced non-small cell lung cancer.Methods Forty-six patients with advanced non-small cell lung cancer were randomly divided equally into two groups.Patients in experimental group were treated with gemcitabine and cisplatin chemotherapy regimen(GP)combined with Kangai injection,while patients in the control were just treated with GP regimen chemotherapy.The expression levels of serum vascular endothelial growth factor(sVEGF)were measured by ELISA before and after the treatment,respectively.Results The sVEGF levels of all patients with advanced NSCLC were obviously higher than that of health controls(P<0.05).And the level of sVEGF in squamous cell cancer group was higher than that in adenocarcinoma,large cell carcinoma or adenosquamous carcinoma group,respectively(P<0.05),while there was no significant difference between the latter 3 groups(P>0.05).Compared the well differentiated group,the sVEGF level of moderately and poorly defferentiated group was increased with no significance(P>0.05).The sVEGF level was obviously decreased in two groups after the treatments(P<0.05).Furthermore,the sVEGF level was significantly decreased combination therapy group than that in chemotherapy group(P<0.05).Conclusion Kangai injection might decrease the expression of serum VEGF in patients with advanced non-small cell lung cancer which suppressed neovascularization.Serum VEGF could be a biomarker for lung cancer diagnosis and therapeutic effect of chemotherapy or biotherapy. |
来源
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肿瘤防治研究
,2011,38(5):545-547 【扩展库】
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关键词
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肺癌
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康艾注射液
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化疗
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血管内皮生长因子
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地址
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广州市第一人民医院呼吸内科, 广州, 510180
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语种
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中文 |
文献类型
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研究性论文 |
ISSN
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1000-8578 |
学科
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肿瘤学 |
文献收藏号
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CSCD:4213403
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参考文献 共
9
共1页
|
1.
胡瑛. 非小细胞肺癌患者术后血清VEGF、 MMP-9动态变化的研究.
中国肺癌杂志,2008,11(5):734-738
|
被引
1
次
|
|
|
|
2.
王小莉. EphA2、VEGF在非小细胞肺癌中的表达及意义.
肿瘤防治研究,2007,34(5):334-336
|
被引
3
次
|
|
|
|
3.
王水利. 非小细胞肺癌患者血清血管内皮生长因子的含量及其临床意义.
中国医师杂志,2006,8(5):691-692
|
被引
1
次
|
|
|
|
4.
江丰收. 非小细胞肺癌患者血清VEGF表达水平及其临床意义.
临床肿瘤学杂志,2008,13(4):325-328
|
被引
2
次
|
|
|
|
5.
顾爱琴. 非小细胞肺癌患者血清VEGF和bFGF检测的临床意义.
上海交通大学学报(医学版):,2008,28(9):1087-1090
|
被引
2
次
|
|
|
|
6.
张斌杰. 非小细胞肺癌患者血清中VEGF动态变化规律的临床意义.
临床肺科杂志,2008,13(10):1274-1275
|
被引
1
次
|
|
|
|
7.
Shimanuki Y. Role of setum vascular endothelial growth factor in the prediction of angiogenesis and prognosis for non-small cell lung cancer.
Lung,2005,183(1):29-42
|
被引
20
次
|
|
|
|
8.
王小侠. 恶性肿瘤患者血清VEGF、IL-8水平与化疗疗效关系的研究.
标记免疫分析与临床,2007,14(3):131-134
|
被引
1
次
|
|
|
|
9.
Ham YM. SEK1-dependent JNK1 activation prolongs cell survival during G-Rh2-induced apoptosis.
Biochem Biophys Res Commun,2003,304(2):358-364
|
被引
9
次
|
|
|
|
|