大脑皮层-背侧纹状体通路在吗啡强迫性觅药和用药行为中的作用
The Role of the Cortex-Dorsal Striatum Pathway in Morphine-Induced Compulsive Drug Seeking and Taking Behaviors
查看参考文献70篇
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文摘
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药物成瘾是以强迫性觅药和用药行为为核心特征的慢性脑疾病。从初始用药到强迫性用药是成瘾者的觅药行为从目标导向性向习惯化发展的过程。强迫性觅药和用药行为是依赖于背外侧纹状体的习惯化行为,同时前额叶皮层-背内侧纹状体通路对行为的控制减弱,导致感觉运动皮层-背外侧纹状体通路对行为的控制持续占主导地位,是成瘾行为具有强迫性特征的重要神经基础。本项目围绕这一重要问题展开研究,在建立具有成瘾特征的动物模型的基础上,采用行为学、行为药理学和组织形态学等方法揭示皮层-纹状体通路在强迫性觅药和用药行为中的作用。研究结果有望为进一步寻找该神经网络参与成瘾行为的分子机制提供重要线索。 |
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其他语种文摘
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Drug addiction is a chronic brain disease characterized by compulsive drug seeking and taking behaviors.From initially go-directed drug use to compulsive drug taking,the drug-seeking behavior in addicts becomes more and more habitual.Compulsive drug seeking and taking behaviors are habitual behaviors depending on dorsolateral striatum,and the impaired function of the prefrontal cortex-dorsomedial striatum pathway,which leads to persistent control of behavior by sensorimotor cortex-dorsolateral striatum pathway,is an important neural mechanism underlying compulsive addicted behaviors.The study will establish the animal model of drug addiction and adopt behavioral,behavioral pharmacological and morphological techniques to discover the role of the cortex-striatum pathway in compulsive drug seeking and taking behaviors.The results may shed light on the possible molecular mechanisms involved in drug addiction. |
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来源
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心理科学进展
,2011,19(5):633-644 【核心库】
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关键词
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强迫性觅药行为
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背外侧纹状体
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前额叶皮层
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前额叶皮层-背内侧纹状体通路
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地址
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中国科学院心理研究所健康与遗传心理学研究室, 北京, 100101
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1671-3710 |
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学科
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社会科学总论 |
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基金
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国家自然科学基金青年项目
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文献收藏号
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CSCD:4210485
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参考文献 共
70
共4页
|
|
1.
Ahmed S H. Transition from moderate to excessive drug intake:Change in hedonic set point.
Science,1998,282(5387):298-300
|
被引
11
次
|
|
|
|
|
2.
Ahmed S H. Persistent increase in the motivation to take heroin in rats with a history of drug escalation.
Neuropsychopharmacology,2000,22(4):413-421
|
被引
6
次
|
|
|
|
|
3.
Alloway K D. Topography of cortical projections to the dorsolateral neostriatum in rats:Multiple overlapping sensorimotor pathways.
Journal of Comparative Neurology,2006,499(1):33-48
|
被引
3
次
|
|
|
|
|
4.
Badiani A. Modulation of morphine sensitization in the rat by contextual stimuli.
Psychopharmacology,2000,151(2/3):273-282
|
被引
3
次
|
|
|
|
|
5.
Badiani A. Drug-induced neurobehavioral plasticity:the role of environmental context.
Behavioural Pharmacology,2004,15(5/6):327-339
|
被引
5
次
|
|
|
|
|
6.
Balleine B W. Goal-directed instrumental action:contingency and incentive learning and their cortical substrates.
Neuropharmacology,1998,37(4/5):407-419
|
被引
5
次
|
|
|
|
|
7.
Balleine B W. The integrative function of the basal ganglia in instrumental conditioning.
Behavioural Brain Research,2009,199(1):43-52
|
被引
5
次
|
|
|
|
|
8.
Belin D. Parallel and interactive learning processes within the basal ganglia:Relevance for the understanding of addiction.
Behavioural Brain Research,2009,199(1):89-102
|
被引
3
次
|
|
|
|
|
9.
Bozarth M A. Toxicity associated with long-term intravenous heroin and cocaine self-administration in the rat.
JAMA,1985,254(1):81-83
|
被引
2
次
|
|
|
|
|
10.
Briand L A. Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended,but not limited,access to self-administered cocaine.
Neuropsychopharmacology,2008,33(12):2969-2980
|
被引
2
次
|
|
|
|
|
11.
Browman K E. The influence of environment on the induction of sensitization to the psychomotor activating effects of intravenous cocaine in rats is dose-dependent.
Psychopharmacology(Berl),1998,137(1):90-98
|
被引
6
次
|
|
|
|
|
12.
Browman K E. Modulatory effect of environmental stimuli on the susceptibility to amphetamine sensitization:a dose-effect study in rats.
Journal of Pharmacology and Experimental Therapeutics,1998,287(3):1007-1014
|
被引
2
次
|
|
|
|
|
13.
Brown V J. Rodent models of prefrontal cortical function.
Trends in Neurosciences,2002,25(7):340-343
|
被引
4
次
|
|
|
|
|
14.
Cardinal R N. Role of the anterior cingulate cortex in the control over behavior by Pavlovian conditioned stimuli in rats.
Behavioral Neuroscience,2003,117(3):566-587
|
被引
3
次
|
|
|
|
|
15.
Chudasama Y. Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate,infralimbic and orbitofrontal cortex in the rat:differential effects on selectivity,impulsivity and compulsivity.
Behavioural Brain Research,2003,146(1/2):105-119
|
被引
3
次
|
|
|
|
|
16.
Corbit L H. The role of prelimbic cortex in instrumental conditioning.
Behavioural Brain Research,2003,146(1/2):145-157
|
被引
3
次
|
|
|
|
|
17.
Corbit L H. Lesions of mediodorsal thalamus and anterior thalamic nuclei produce dissociable effects on instrumental conditioning in rats.
European Journal of Neuroscience,2003,18(5):1286-1294
|
被引
1
次
|
|
|
|
|
18.
de Bruin J P. A behavioural analysis of rats with damage to the medial prefrontal cortex using the Morris water maze:evidence for behavioural flexibility,but not for impaired spatial navigation.
Brain Research,1994,652(2):323-333
|
被引
1
次
|
|
|
|
|
19.
Deroche-Gamonet V. Evidence for addiction-like behavior in the rat.
Science,2004,305(5686):1014-1017
|
被引
11
次
|
|
|
|
|
20.
Devan B D. Effects of medial and lateral caudate-putamen lesions on place-and cue-guided behaviors in the water maze:relation to thigmotaxis.
Behavioural Brain Research,1999,100(1/2):5-14
|
被引
1
次
|
|
|
|
|
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