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Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidinyl Group

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文摘 A series of 2-amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidinyl substituted diaryl urea derivatives was designed and synthesized. Their in vitro cytotoxicities against two cancer cell lines(Bel-7402 and A549) were evaluated by standard MTT assay. Six of tested compounds 6, 8, 10, 17, 21 and 22 exhibited more potent cytotoxicity superior to sorafenib. The structure activity relationship(SAR) study indicates that 2-amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidinyl group was an option for cytotoxic potency
来源 Chemical Research in Chinese Universities ,2010,26(4):558-562 【核心库】
关键词 Diaryl urea ; 2-Amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine ; Cytotoxicity
地址

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Key Lab of New Drugs Design and Discovery of Liaoning Province, Shenyang, 110016

语种 英文
文献类型 研究性论文
ISSN 1005-9040
学科 化学
文献收藏号 CSCD:4099164

参考文献 共 9 共1页

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引证文献 1

1 Zhai Xin Syntheses and Antiproliferative Activities of Novel Diarylthiosemicarbazide Derivatives Chemical Research in Chinese Universities,2013,29(1):62-66
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