Synthesis and Cytotoxicity of Novel Diaryl Ureas Containing 2-Amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidinyl Group
查看参考文献9篇
文摘
|
A series of 2-amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidinyl substituted diaryl urea derivatives was designed and synthesized. Their in vitro cytotoxicities against two cancer cell lines(Bel-7402 and A549) were evaluated by standard MTT assay. Six of tested compounds 6, 8, 10, 17, 21 and 22 exhibited more potent cytotoxicity superior to sorafenib. The structure activity relationship(SAR) study indicates that 2-amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidinyl group was an option for cytotoxic potency |
来源
|
Chemical Research in Chinese Universities
,2010,26(4):558-562 【核心库】
|
关键词
|
Diaryl urea
;
2-Amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
;
Cytotoxicity
|
地址
|
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Key Lab of New Drugs Design and Discovery of Liaoning Province, Shenyang, 110016
|
语种
|
英文 |
文献类型
|
研究性论文 |
ISSN
|
1005-9040 |
学科
|
化学 |
文献收藏号
|
CSCD:4099164
|
参考文献 共
9
共1页
|
1.
Bikker J A.
J Med. Chem,2009,52(6):1493
|
被引
10
次
|
|
|
|
2.
Dai Y J.
J Med. Chem,2005,48(19):6066
|
被引
8
次
|
|
|
|
3.
Dai Y.
J. Med Chem,2007,50(7):1584
|
被引
8
次
|
|
|
|
4.
Gong L Y.
Bioorg. Medl. Chem. Letters,2003,13(20):3597
|
被引
1
次
|
|
|
|
5.
Fukui H K I.
Heterocycles,2002,56(1/2):257
|
被引
1
次
|
|
|
|
6.
Mitsuya M.
J. Med. Chem,2000,43(26):5017
|
被引
7
次
|
|
|
|
7.
De Lucca V G.
J. Med. Chem,2002,45(17):3794
|
被引
1
次
|
|
|
|
8.
Slocombe R J.
J. Am. Chem. Soc,1950,72(5):1888
|
被引
1
次
|
|
|
|
9.
Han Y.
Chemical Reagents,2002,24(6):375
|
被引
1
次
|
|
|
|
|