Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors
查看参考文献35篇
|
文摘
|
Brain-derived neurotrophic factor (BDNF) can significantly promote nerve regeneration and repair. High expression of the BDNF-green fluorescent protein (GFP) gene persists for a long time after transfection into neural stem cells. Nevertheless, little is known about.the biological characteristics of BDNF-GFP modified nerve stem cells in vivo and their ability to induce BDNF expression or repair spinal cord injury. In the present study, we transplanted BDNF-GFP transgenic neural stem cells into a hemisection model of rats. Rats with BDNF-GFP stem cells exhibited significantly increased BDNF expression and better locomotor function compared with stem cells alone. Cellular therapy with BDNF-GFP transgenic stem cells can improve outcomes better than stem cells alone and may have therapeutic potential for spinal cord injury |
|
来源
|
Neural Regeneration Research
,2010,5(17):1303-1307 【核心库】
|
|
DOI
|
10.3969/j.issn.1673-5374. 2010.17.004
|
|
关键词
|
neural stem cells
;
brain-derived neurotrophic factor
;
transplantation
;
green fluorescent protein
;
spinal cord injury
;
neural regeneration
|
|
地址
|
Department of Orthopedics, First Affiliated Hospital of China Medical University, Liaoning, Shenyang, 110001
|
|
语种
|
英文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
1673-5374 |
|
学科
|
神经病学与精神病学 |
|
基金
|
辽宁省自然科学基金
|
|
文献收藏号
|
CSCD:4041465
|
参考文献 共
35
共2页
|
|
1.
Salehi M. Repair of spinal cord injury by co-transplantation of embryonic stem cell-derived motor neuron and olfactory ensheathing cell.
Iran Biomed J,2009,13(3):125-135
|
被引
13
次
|
|
|
|
|
2.
Ryu HH. Functional recovery and neural differentiation after transplantation of allogenic adipose-derived stem cells in a canine model of acute spinal cord injury.
J Vet Sci,2009,10(4):273-284
|
被引
12
次
|
|
|
|
|
3.
Kumagai G. Roles of ES cell-derived gliogenic neural stem/progenitor cells in functional recovery after spinal cord injury.
PLoS One,2009,4(11):e7706
|
被引
4
次
|
|
|
|
|
4.
Yaguchi M. Transplantation of dendritic cells promotes functional recovery from spinal cord injury in common marmoset.
Neurosci Res,2009,65(4):384-392
|
被引
2
次
|
|
|
|
|
5.
Maeda K. Transplantation of Von Hippel-Lindau peptide delivered neural stem cells promotes recovery in the injured rat spinal cord.
Neuroreport,2009,20(17):1559-1563
|
被引
5
次
|
|
|
|
|
6.
Okada S. vivo imaging of engrafted neural stem cells: its application in evaluating the optimal timing of transplantation for spinal cord injury.
FASEB J,2005,19(13):1839-1841
|
被引
13
次
|
|
|
|
|
7.
Lu P. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury.
Exp Neurol,2003,181(2):115-129
|
被引
98
次
|
|
|
|
|
8.
Parr AM. Transplanted adult spinal cord-derived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury.
Neuroscience,2008,155(3):760-770
|
被引
22
次
|
|
|
|
|
9.
Salewski RP. Are induced pluripotent stem cells the future of cell-based regenerative therapies for spinal cord injury?.
J Cell Physiol,2010,222(3):515-521
|
被引
5
次
|
|
|
|
|
10.
Kamei N. BDNF, NT-3, and NGF released from transplanted neural progenitor cells promote corticospinal axon growth in organotypic cocultures.
Spine,2007,32(12):1272-1278
|
被引
38
次
|
|
|
|
|
11.
Sasaki M. BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury.
J Neurosci,2009,29(47):14932-14941
|
被引
29
次
|
|
|
|
|
12.
Koyama R. Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the dentate gyrus.
J Neurosci,2004,24(33):7215-7224
|
被引
5
次
|
|
|
|
|
13.
Wang YF. Neural stem cells transplantation promote the expressions of brain derived neurotrophic factor after the spinal cord injury of rats.
Zhongguo Gu Shang,2008,21(11):836-838
|
被引
2
次
|
|
|
|
|
14.
Hwang DH. Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injury.
BMC Neurosci,2009,10:117
|
被引
28
次
|
|
|
|
|
15.
Li W. Repair of spinal cord injury by neural stem cells modified with BDNF gene in rats.
Neurosci Bull,2006,22(1):34-40
|
被引
12
次
|
|
|
|
|
16.
Li SH. Construction of Ad-EGFP-BDNF vector and its expressing in NSCs.
Zhongguo Xiandai Yixue Zazhi,2008,18(1):76-79
|
被引
1
次
|
|
|
|
|
17.
Altar CA. Anterograde transport of brain-derived neurotrophic factor and its role in the brain.
Nature,1997,389(6653):856-860
|
被引
16
次
|
|
|
|
|
18.
Ramer MS. Functional regeneration of sensory axons into the adult spinalcord.
Nature,2000,403(6767):312-316
|
被引
22
次
|
|
|
|
|
19.
Vavrek R. BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats.
Brain,2006,129(6):1534-1545
|
被引
23
次
|
|
|
|
|
20.
Scharfman H. Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats.
Exp Neurol,2005,192(2):348-356
|
被引
25
次
|
|
|
|
|
了解气象卫星更多信息，请访问