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奥沙利铂联合卡培他滨治疗38例晚期胃癌的疗效
Oxaliplatin Plus Capecitabine for Advanved Gastric Cancer: Report of 38 Cases

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管梅 1   张路 2   赵林 1   白春梅 1 *  
文摘 目的探讨奥沙利铂联合卡培他滨(XELOX)方案治疗晚期胃癌的疗效和安全性.方法回顾性分析2004年5月至2009年10月北京协和医院肿瘤内科收治的使用XELOX方案治疗晚期胃癌患者38例.化疗方案:奥沙利铂静滴2h,第1天给药;卡培他滨分2次口服,第1~14天给药;每3周重复.按实体瘤的疗效评价标准评价疗效,按美国国立癌症研究所的常见不良反应判定标准评价毒副反应.结果 3周期后评价疗效:一线化疗34例,二线化疗4例.一线化疗患者中32例可评估,完全缓解0例(0.0%),部分缓解8例(25.0%),疾病稳定14例(43.8%),疾病进展10例(31.2%).中位随访9.5个月(4~46个月),23例出现疾病进展,中位无进展生存时间为7.0个月(95%CI为4.5~9.5个月);20例已死亡(均为肿瘤相关死亡),中位总生存时间为12.0个月(95%CI为9.8~14.2个月);1年生存率40.6%,2年生存率23.7%.3~4度不良反应主要有粒细胞减少(10.5%),血小板减少(2.6%),恶心(7.9%),呕吐(5.3%).结论 XELOX作为一线化疗方案治疗晚期胃癌有效,安全
其他语种文摘 Objective To evaluate the efficacy and toxicity of the combination chemotherapy of oxali-platin with capecitabine(XELOX)in patients with advanced gastric cancer. Methods Thirty-eight advanced gastric cancer patients who received XELOX regimen during 2004-2009 were analyzed retrospectively. The combination chemotherapy included oxaliplatin as 2-hour infusion on day 1 and capecitabine po bid on days 1 to 14. Treatment was repeated every 3 weeks. Results XELOX regime was applied as first-line therapy in 34 pa-tients and as second-line therapy in 4 patients. After three cycles of chemotherapy, the outcomes in 32 patients who received XELOX as the first-line therapy included partial response(n = 8,25.0%), stable disease(n = 14,43.8%), and progressive disease(n = 10,31.2%);no patient achieved complete response. The median time to progression and overall survival time were 7.0 months(95% CI:4.5-9.5 months)and 12 months(95% CI:9.8-14.2 months), respectively. One-year and two-year survival rates were 40.6% and 23.7%, respectively. Grade 3-4 toxicities including neutropenia(10.5%), thrombocytopenia(2.6%), nausea(7.9%), and vomitting(5.3%)were noted in a few patients. Conclusion XELOX regimen can be effectively and safely applied as first-line treatment for advanced gastric cancer patients
来源 中国医学科学院学报 ,2010,32(4):407-411 【核心库】
DOI 10.3881/j.issn.1000-503x.2010.04.010
关键词 晚期胃癌 ; 奥沙利铂 ; 卡培他滨
地址

1. 中国医学科学院北京协和医学院北京协和医院肿瘤内科, 北京, 100730  

2. 中国医学科学院北京协和医学院北京协和医院物理康复科, 北京, 100730

语种 中文
文献类型 研究性论文
ISSN 1000-503X
学科 肿瘤学
文献收藏号 CSCD:4031450

参考文献 共 12 共1页

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引证文献 1 篇

1 迟惠昌 益气活血中药配合化学药物治疗晚期胃癌疗效观察 中华中医药杂志,2011,26(8):1888-1890
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