抗抑郁药物基因组学研究进展
查看参考文献20篇
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文摘
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抑郁障碍是最常见的精神疾病,人群中几乎1/5者在其一生中经历过重性抑郁障碍(major depressive disorder, MDD)的发作.尽管目前药物是治疗抑郁障碍最有效方法,仍存在诸多疑惑,如:单一抗抑郁药物治疗抑郁障碍即使在足量足疗程的给药条件下仅30% ~45%的患者获得临床症状的完全缓解[1];且症状缓解存在延迟反应,时间从数周至数月不等;另有10%的患者对于任何种类的抗抑郁药物治疗均无效.即使在规范用药的情况下仍有很高的疾病复发率.究竟是怎样的原因导致治疗的个体差异?既往我们所熟知个体药效差异主要受个体营养状况,联合用药等因素影响,随着人类基因组学的发展,发现遗传因素对个体治疗差异性有着重要影响.药物基因组学就是针对基因与药物在不同人群个体内作用的差异性进行研究.药物基因组学可运用于抗抑郁药物新的治疗靶点研发,预测抗抑郁药物治疗的反应性,这对于治疗学尤其重要.目前对于抑郁症的治疗主要是消除或减少临床症状,临床医生对于抗抑郁药物的选择多基于个人的用药经验而非客观指标,药物基因组学研究的引入使得基因导向型个体化治疗成为可能 |
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来源
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中国神经精神疾病杂志
,2010,36(9):573-576 【核心库】
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关键词
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抗抑郁药物
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药物基因组学
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药物代谢
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药效动力学
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地址
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1.
昆明医学院第一附属医院精神科, 昆明, 650031
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中国科学院昆明植物所植化室
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玉溪市第二人民医院
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1002-0152 |
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学科
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神经病学与精神病学 |
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基金
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云南省科技厅-昆明医科大学联合专项基金
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云南省卫生科技计划项目
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文献收藏号
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CSCD:4014339
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