石榴花多酚对2型糖尿病大鼠血管内皮的保护作用
Protective effect of PFP on blood vessel endothelium of type 2 diabetes rats
查看参考文献10篇
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文摘
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目的:通过观察血浆中血管紧张素Ⅱ(ATⅡ)、内皮素1(ET-1)、血栓素B(TXB2)和6酮-前列腺素(6-Keto-PGF1a)的变化,研究石榴花多酚(Pomegranate Flower polyphenol,PFP)对2型糖尿病伴高血脂大鼠血管内皮的保护作用. 方法:通过腹腔注射链脲佐菌素(STZ)45mg/kg,加高脂饲料喂养建立的2型糖尿病大鼠模型,将成模大鼠随机分为模型组和两个给药剂量组,另设正常对照组,在接受石榴花多酚治疗4周后,测定其相关指标. 结果:给药四周后,各组空腹血糖、血浆中ATⅡ、ET-1、TXB2和6-Ke-to-PGF1a差异均有统计学意义(P<0.05~0.01). 结论:石榴花多酚对糖尿病大鼠的血管内皮有一定的保护作用 |
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其他语种文摘
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Objective: To study the protective effect of pomegranate flower polyphenol(PFP) on blood vessel endothelium(BVE) of type 2 diabetes mellitus(DM) rats. Methods: Model group was established with high calorie feeding and small dose injection of STZ(45 mg/kg).DM rats were randomly assigned to model group,PFP high dose group,PFP low dose group and normal control group. After 4weeks treatment with PFP,FPG,ET-1,TXB2,ATⅡand 6-Keto-PGF1a were detected. Result: PFP could decrease FPG,ET-1,TXB2,ATⅡconcentration of DM rats and increase 6-Keto-PGF1a concentration of DM rats. Indexs of each group showed significant difference(P<0.05~0.01). Conclusion: The results suggest that PFP could be used to protect BVE of DM rats |
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来源
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中药药理与临床
,2010,26(4):25-27 【扩展库】
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关键词
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石榴花多酚
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2型糖尿病
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血管内皮
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内皮素-1
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血管紧张素Ⅱ
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血栓素B2
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6酮-前列腺素1a
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地址
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1.
新疆医科大学生理学教研室, 乌鲁木齐, 830011
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新疆医科大学药理学教研室, 乌鲁木齐, 830011
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新疆医科大学中国科学院新疆理化技术研究所, 乌鲁木齐, 830011
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1001-859X |
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学科
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临床医学 |
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基金
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新疆维吾尔自治区科技攻关(含重大专项)和重点项目计划,项目编号
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文献收藏号
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CSCD:4008762
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