食欲素神经肽在应激过程中的作用
The Role of Orexin in Stress
查看参考文献43篇
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文摘
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食欲素因其在调节能量代谢、睡眠和唤醒等生理功能中的作用而备受关注.近年来研究逐渐发现,食欲素参与应激和奖赏过程的调节,特别是其在药物成瘾过程中的作用是目前的研究热点.主要介绍食欲素系统与应激相关系统之间的神经联系,阐述了其在应激相关的生理、神经内分泌与行为反应中的作用.并进一步介绍了食欲素系统在应激诱发药物成瘾复吸过程中的作用.食欲素对应激反应的调控作用具有相对特异性,受应激的种类、其他应激相关神经递质系统及食欲素神经元的投射通路等多种因素影响. |
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其他语种文摘
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Orexins(hypocretins)are novel neuropeptides released by some neurons identified in lateral hypothalamus. They are involved in the regulation of energy metabolism, neuroendocrine, sleep and waking. Recently, more and more evidence have shown that orexins play a key role in the stress and reward including drug addiction. The evidence was sumarized, showing that orexin neurons are well positioned to regulate stress-related neural systems, and orexin systems are involved in the physiological, neuroencocrine, psychological and behavioral process of stress. More recently, the role of orexins in stress-induced relapse of drug abuse has been established. All these evidence implicated that orexin system play a critical role in the process of stress, and their role in stress is dependent on the type of stress, their distribution and connection to other stress-related neurotransmitter systems. |
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来源
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生物化学与生物物理进展
,2010,37(7):713-719 【核心库】
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DOI
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10.3724/sp.j.1206.2010.00047
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关键词
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食欲素
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应激
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药物成瘾
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复吸
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地址
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1.
中国科学院研究生院, 北京, 100049
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中国科学院心理研究所心理健康重点实验室, 北京, 100101
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1000-3282 |
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学科
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生物化学 |
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基金
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国家自然科学基金面上项目
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中国科学院心理研究所青年基金资助项目
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中国科学院知识创新工程重要方向项目
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国家973计划
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文献收藏号
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CSCD:3923784
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参考文献 共
43
共3页
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