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抑郁症的内表现型:快感缺失及其测量方法
Endophenotype of Depression: Anhedonia and Its Measurements

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刘文华 1   陈楚侨 2 *   黄敏 3  
文摘 快感缺失,指的是体验快乐的能力下降,广泛出现在抑郁症中,但同时也是其他如精神分裂症的重要症状.虽然快感缺失在精神病理学上非常重要,但较少受到研究重视.文章探讨了抑郁症和快感缺失的关系以及快感缺失个体的大脑奖励系统受损的神经机制,同时介绍了快感缺失可以进一步区分为期待性和消费性两种损害类型以及研究所用的主客观测量方法.指出快感缺失作为抑郁症最有可能的内表现型及其对疾病发展的作用,需要进一步研究深入.
其他语种文摘 Anhedonia is defined as the diminished capacity to experience pleasure, which is widely recognized to occur in depression, and is a prominent feature that is involved in several types of psychiatric disorders and maladaptive behaviors. Although anhedonia is regarded as an important symptom in psychopathology, it has received relatively little attention. To better understand the role of anhedonia in depression, this paper reviews the relationship between depression and anhedonia, and the neural substrates of anhedonia linked to a dysfunction of the dopaminergic reward system. It also highlights two facets of hedonic capacity (anticipatory and consummatory pleasure) and addresses some measurement issues of anhedonia. Further research is needed to be conducted in the near future to explore whether anhedonia might be the most possible endophenotype of depression and the role in development of depression.
来源 心理科学进展 ,2010,18(2):271-281 【扩展库】
关键词 快感缺失 ; 抑郁症 ; 神经基础 ; 大脑奖励系统 ; 测量
地址

1. 广州医学院人文社会科学学院应用心理学系, 广东, 广州, 510182  

2. 中国科学院,心理研究所神经心理与应用认知科学实验室, 心理健康院重点实验室, 北京, 100101  

3. 中山大学教育学院心理学系, 广东, 广州, 510275

语种 中文
文献类型 研究性论文
ISSN 1671-3710
学科 基础医学
基金 中国科学院心理研究所百人计划 ;  中国科学院知识创新工程项目 ;  中山大学百人计划
文献收藏号 CSCD:3868523

参考文献 共 76 共4页

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引证文献 9

1 史艳芳 精神分裂症谱系中的快感缺乏 心理科学进展,2010,18(9):1430-1439
被引 4

2 杨新华 抑郁症快感缺失:概念及其神经生物学基础 中国临床心理学杂志,2013,21(5):747-750
被引 4

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