Role of RECK methylation in gastric cancer and its clinical significance
查看参考文献20篇
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文摘
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AIM: To investigate the relation between RECK methylation and clinicopathological characteristics of gastric cancer patients and evaluate the role of RECK methylation in peritoneal metastasis of gastric cancer.METHODS: Methylation of RECK gene in 40 paired samples of gastric cancer and its corresponding adjacent normal mucosa, lymph nodes and peritoneal irrigation fluid was detected by methylation-specific polymerase chain reaction.RESULTS: Aberrant methylation of RECK gene was detected in 27.5% (11/40) of the adjacent normal mucosa samples, in 47.5% (19/40) of gastric cancer samples, in 57.1% (12/21) of the lymph node samples,and in 35% (14/40) of peritoneal irrigation fluid samples,respectively, with a significant difference between the adjacent normal mucosa and lymph node samples ( P=0.023). Presence of RECK methylation in the primary tumor samples was significantly correlated with tumor invasion ( P=0.023). The accuracy of RECK methylation in peritoneal lavage fluid samples for the diagnosis of peritoneal metastasis of gastric cancer was 72.5% (26/40), with a sensitivity of 66.7% (6/9) and a specificity of 74.2% (23/31).CONCLUSION: Aberrant methylation of RECK gene may provide useful information for the early diagnosis and treatment of peritoneal metastasis of gastric cancer. |
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来源
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World Journal of Gastroenterology
,2010,16(7):904-908 【核心库】
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关键词
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RECK gene
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Hypermethylation
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Gastric cancer
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Metastasis
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Peritoneal lavage fluid
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地址
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Department of Surgical Oncology,the First Affiliated Hospital China Medical University, Liaoning, Shenyang, 110001
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1007-9327 |
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学科
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内科学 |
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基金
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国家自然科学基金
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the Foundation of Education Bureau of Liaoning Province
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文献收藏号
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CSCD:3821205
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20
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