固相萃取-硅烷化-气质联用分析尿中莠去津及其去烃基代谢物
Solid Phase Extraction-Silyl Derivation-Gas Chromatography-Mass Spectrometry for the Analysis of Atrazine and Its N-Desalkalated Metabolites in Urine
查看参考文献9篇
|
文摘
|
建立了固相萃取-硅烷化-气质联用分析尿中除草剂莠去津(ATRZ)及其代谢物去异丙基莠去津(DIA)、去乙基莠去津(DEA)和去乙基去异丙基莠去津(DDA)的方法.尿样加入内标,碱化后用GDX_(501)大孔树脂进行固相萃取,萃取物进行TMS衍生化,选择离子监测气质联用法分析.尿中ATRZ、DIA、DEA和DDA的提取率分别为85.3%、78.6%、80.2%和71.7%; 检出限分别为0.9、0.9、1.5和1.2 μg/L;在5～500 μg/L浓度范围内工作曲线的线性关系良好.方法可用于莠去津中毒者和职业接触者尿样的分析. |
|
其他语种文摘
|
A solid phase extraction-trimethylsilyl (TMS) derivation-gas chromatography/mass spectrometric method to detect and quantitate atrazine and its metabolites [deisopropylatrazine (DIA) , deethylatrazine (DEA) and didealkyl atrazine (DDA)] in urine was developed. The urine samples were basified, and extracted by solid phase extraction technique using GDX501 porous resin . The resulting extracts were TMS derivat-ized, and then analysed by gas chromatography-mass spectrometry in the selected ion monitoring mode. The extraction recoveries of atrazine, DIA, DEA and DDA in urine were 85.3% , 78.6% , 80.2% and 71.7% ,respectively. The limit of detection of atrazine, DIA, DEA and DDA in urine were 0. 9, 0. 9, 1.5 and 1.2 μg/L, respectively. The linearity relationship were good in the concentration range of 5 - 500 μg/L for all 4 analytes in urine. This analytical method can be applied to the analysis of specimens of humen poisoned with atrazine or occupationaly exposed to atrazine. |
|
来源
|
分析化学
,2009,37(3):441-444 【核心库】
|
|
关键词
|
除草剂
;
莠去津
;
尿
;
气质联用法
;
硅烷基衍生化
;
固相萃取法
|
|
地址
|
中国刑事警察学院法医系, 辽宁, 沈阳, 110035
|
|
语种
|
中文 |
|
文献类型
|
研究性论文 |
|
ISSN
|
0253-3820 |
|
学科
|
化学 |
|
基金
|
公安部科技创新项目
|
|
文献收藏号
|
CSCD:3752117
|
参考文献 共
9
共1页
|
|
1.
Ross M K.
Analytical Biochemistry,2006,351:161-173
|
被引
2
次
|
|
|
|
|
2.
Brzezicki Jill M.
Journal of Analytical Toxicology,2003,27:569-573
|
被引
1
次
|
|
|
|
|
3.
Mendas G.
Journal of Chromatography A,2001,918:351-359
|
被引
3
次
|
|
|
|
|
4.
Cai Z.
Analytica Chimica Acta,1995,304:67-73
|
被引
2
次
|
|
|
|
|
5.
Huang S.
Journal of Agricultural and Food Chemistry,2003,51(25):7252-7258
|
被引
1
次
|
|
|
|
|
6.
许人骥. 气相色谱法分析尿液样品中的阿特拉津及其代谢物.
色谱,2007,25(5):758-761
|
被引
8
次
|
|
|
|
|
7.
张新忠. 气相色谱化学电离二级质谱法测定土壤中16种三嗪类除草剂的残留.
分析化学,2008,36(6):781-787
|
被引
20
次
|
|
|
|
|
8.
McLaughlin R A.
Journal of Chromatography A,1997,790:161-167
|
被引
2
次
|
|
|
|
|
9.
Pachinger A.
High Resolution Chromatography,1992,15(5):302-304
|
被引
1
次
|
|
|
|
|
了解气象卫星更多信息，请访问