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心肌细胞大变形黏弹性模型及在实验中的应用
THE NONLINEAR VISCOELASTIC CONSTITUTIVE MODEL OF CARDIAC MYOCYTE IN SIMULATION OF MICROPIPETTE ASPIRATION EXPERIMENT

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唐陶 1   王世骐 2   裘钧 1   庄茁 1  
文摘 在衡量单个细胞力学行为的研究中,越来越多地采用结合实验的数值模拟方法.在连续介质力学框架下,发展了一种新的心肌细胞本构模型,并与微管吮吸实验结合,探讨了心肌细胞的力学特性.本构模型是对普遍使用的仅能用于小变形分析的标准线性固体模型的一种扩展,它将超弹性性能引入到黏弹性模型中,用以描述细胞的大变形黏弹性效应.基于改进的本构模型,对心肌细胞微管吮吸实验过程进行了有限元模拟,并将计算结果与实验结果以及经典理论解进行了对比.结果显示发展的本构模型适合细胞大变形问题的有限元数值模拟.
其他语种文摘 Numerical modeling with experimental analysis is increasingly being used to evaluate the mechan-ical properties of living cells in single cell mechanics. In the present study, through the continuum mechanics process, a new constitutive model for cardiac myocyte is developed, and together with the micropipette aspi-ration experiment, the mechanical property of cardiac myocyte is investigated. The commonly used standard linear solid model is extended into a nonlinear viscoelastic constitutive model in which was introduced the hyperelasticity to describe the large deformation of myocytes in response to micropipette aspiration. Based on the constitutive model and experiment data, the experiment process is simulated, and the computational results are compared with the experiment results and classic theoretical solutions. The results show that the new constitutive model suits the computation of large deformation of cells.
来源 力学学报 ,2009,41(6):913-919 【核心库】
关键词 心肌细胞 ; 大变形 ; 非线性黏弹性本构 ; 微管吮吸实验 ; 数值模拟
地址

1. 清华大学航天航空学院, 北京, 100084  

2. 中国科学院力学研究所, 北京, 100190

语种 中文
文献类型 研究性论文
ISSN 0459-1879
学科 生物物理学;一般工业技术
文献收藏号 CSCD:3715977

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引证文献 2 篇

1 唐陶 周期基底拉伸下心肌细胞重排理论建模及数值计算 清华大学学报. 自然科学版,2010,50(5):660-664
被引 0 次

2 隋成龙(综述) 影响左心室舒张功能因素计算模型的研究进展 生物医学工程学杂志,2013,30(2):447-450
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