Synthesis and Antiproliferative Activity of Novel [1,2,4]Triazolo[1,5-a]pyrimidine-7-amine Derivatives

ZHAI Xin ZHANG Cun-long HE Lei LI Qi WANG Jiu-liang SHEN Xiao-li GONG Ping ^*

文摘	A series of novel N-anilino-2-substituted-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-7-amine derivatives was prepared and evaluated for their in vitro antiproliferative activity against two cancer eell lines.Bel-7402 and HT-1080.Most of the compounds inhibited the cell proliferation at a low concentration.Seven compounds,VI_5,VI_7,VI_(10),and VI_(12)-VI_(15),possessed marked antiproliferative activity superior to that of cisplatin.of these seven initial hits,compound Vl_(10) was the most active.
来源	Chemical Research in Chinese Universities ,2009,25(4):474-479 【核心库】
关键词	[1,2,4]Triazolo[1,5-a]pyrimidines ; Antiproliferative activity ; Anticancer
地址	School ofPharmaceutical Engineering,Shenyang Pharmaceutical University, Key Laboratory of New Drugs Design and Discovery of Liaoning Province, Liaoning, Shenyang, 110016
语种	英文
文献类型	研究性论文
ISSN	1005-9040
学科	化学
文献收藏号	CSCD:3684043

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