扩散张量成像观察先天性耳聋患者脑白质结构
Diffusion tensor imaging observation of brain white matter in congenitally deaf
查看参考文献16篇
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文摘
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目的 利用扩散张量成像(DTI)研究先天性耳聋(CD)患者的脑白质结构,探讨脑白质变化机制.方法 对6名先天性耳聋患者和6名正常人进行脑部DTI扫描,应用基于体素的分析(VBA)对CD组和正常对照(HC)组的全脑分数各向异性(FA)值进行比较,计算样本感兴趣区(ROI)Brodmann(BA)41、BA22和BA44区的平均FA值.结果 CD组FA值显著减少的区域位于右脑的颞上回(STG), ROI平均FA值除在右脑BA22区有下降的趋势外,未发现显著异常;CD组和HC组中左脑ROI的平均FA值显著偏大.结论 先天性耳聋患者右脑STG白质损伤,这种结构异常是由其先天缺乏声音刺激所造成的. |
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其他语种文摘
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Objective To investigate structure of brain white matter in patients with congenitally deaf (CD) with diffusion tensor imaging (DTI), and to probe into the mechanism of CD brain white matter alteration. Methods Fractional anisotropy (FA) of 6 cases of CD and 6 healthy controls (HC) were compared with voxel-based analysis (VBA) in a whole brain manner. Average FA value in Brodmann (BA) 41, 22 and 44 areas of all participators were calculated for statistical analysis. Results Significant FA value decrease was found in CD located in white matter tissue of superior temporal gyrus (STG) in the right hemisphere. No statistical significant difference was found from the two-samples t-test of average FA value in region of interesting (ROD, except that a lower tendency was inspected in BA22 of right hemisphere in CD. Furthermore, leftward asymmetry of FA value was found in both CD and HC. Conclusion White matter integrity damage happens in right auditory association region of CD, which may be corresponding to the lack of auditory input since birth. |
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来源
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中国医学影像技术
,2009,25(4):585-587 【核心库】
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关键词
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扩散张量成像
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先天性耳聋
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白质
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分数各向异性
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地址
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1.
兰州大学信息科学与工程学院, 甘肃, 兰州, 730000
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中国科学院自动化研究所, 模式识别国家重点实验室, 北京, 100080
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首都医科大学宣武医院放射科, 北京, 100053
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1003-3289 |
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学科
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临床医学;耳鼻咽喉科学 |
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基金
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国家自然科学基金
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文献收藏号
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CSCD:3644160
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