大肠杆菌产琥珀酸基因工程研究进展
Advancement in Genetic Engineering for Production of Succinic Acid by Escherichia coli
查看参考文献38篇
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文摘
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生物合成琥珀酸摆脱了对不可再生战略资源石油的依赖,以其社会、经济和环境效益展现出良好的发展前景.野生型大肠杆菌的琥珀酸生产强度难以满足生物合成琥珀酸工业化的要求,但遗传背景清楚,容易改造.近年来,人们深入研究了大肠杆菌的琥珀酸代谢途径,通过强化大肠杆菌琥珀酸合成途径、抑制琥珀酸旁路代谢途径、构建产琥珀酸乙醛酸循环和有氧生产体系等多种基因工程策略,对大肠杆菌进行菌株改造和代谢进化筛选,提高了琥珀酸产量.综述了大肠杆菌产琥珀酸的基因工程研究进展. |
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其他语种文摘
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Bio-based succinic acid could release the dependence of petroleum that is non-renewable resource, and is benefit for society, economy and environment. Esckerichia coli naturally produces succinic acid as a minor fermentation product, however, its genetic background is quite clear and modified easily by genetic engineering for bio-based succinic acid industrialization. In recent years, researchers focused on the metabolic pathway of succinic acid, and a variety of genetic approaches were developed to reconstruct Eseherickia coli, such as overexpression of the endogenous or heterologous CO_2-fixing enzymes in Escherichia coli directed the carbon flow to succinic acid, inactivation of the competing pathways of succinic acid production, as well as construction of the glyoxylate shunt and aerobic system for succinic acid production, the production of succinic acid was increased significantly. Here, the advancement of succinic acid production in Esckerichia coli by genetic engineering was reviewed. |
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来源
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中国生物工程杂志
,2009,29(7):108-117 【核心库】
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关键词
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琥珀酸
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大肠杆菌
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基因工程
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地址
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1.
中国矿业大学(北京)化学与环境工程学院生物工程系, 北京, 100083
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中国科学院过程工程研究所, 北京, 100080
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1671-8135 |
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学科
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分子生物学 |
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基金
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国家863计划
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文献收藏号
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CSCD:3620484
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参考文献 共
38
共2页
|
|
1.
.
http://www.brdisolutions.com/pdfs/BioProduetsOpportunitiesReportFinal.pdf
|
被引
1
次
|
|
|
|
|
2.
凌关庭.
食品添加剂手册(第二版),1991:638-639
|
被引
1
次
|
|
|
|
|
3.
Wilke D. What should and what can bioteehnology contribute tochemical bulk production?.
FEMS Microbiology Reviews,1995,16:89-100
|
被引
4
次
|
|
|
|
|
4.
Wilke D. Chemicals from biotechnology:molecular plant genetics will challenge the chemical and fermentation industry.
Applied Microbiology and Biotechnology,1999,52:135-145
|
被引
3
次
|
|
|
|
|
5.
Willke T. Industrial bioconversion of renewable resources as an alternative to conventional chemistry.
Applied Microbiology and Biotechnology,2004,66:131-142
|
被引
33
次
|
|
|
|
|
6.
Song H. Production of succinic acid by bacterial fermentation.
Enzyme and Microbial Technology,2006,39:353-361
|
被引
2
次
|
|
|
|
|
7.
James B. Prospects for a biobased succinate industry.
Applied Microbiology and Biotechnology,2007,76:727-740
|
被引
1
次
|
|
|
|
|
8.
Vemuri G N. Succinate production in dual-phase Escherichia coli fermentations depends on the time of transition from aerobic to anaerobic condltions.
Journal of Industrial Microbiology and Biotechnology,2002,28:325-332
|
被引
29
次
|
|
|
|
|
9.
Jantama K. Combining metabolic engineering and metabolic evolution to develop nonrecombinant strains of Escherichia coli C that produce succinate and malato.
Biotechnology and Bioengineering,2008,99(5):1140-1153
|
被引
32
次
|
|
|
|
|
10.
Lin H. Metabolic engineering of aerobic succinate production systems in Escherichia coli to improve process productivity and achieve the maximum theoretical suocinate yield.
Memb Eng,2005,7:116-127
|
被引
1
次
|
|
|
|
|
11.
Lin H. Chemostat culture characterization of Escherichia coli mutant strains metabolically engineered for aerobic succinate production:A study of the modified metabolic network based on metabolite profile,enzyme activity,and gene expression profile.
Metabolic Engineering,2005,7:337-352
|
被引
9
次
|
|
|
|
|
12.
Clark D P. The fermentation pathways of Escherichia coli.
FEMS Microbiol Bev,1989,63:223-234
|
被引
26
次
|
|
|
|
|
13.
Chen Y. Analysis of Exherichia coli anaplerotic metabolism and its regulation mechanisms from the metabolic responses to altered dilution rates and phosphoenolpymvate carboxykinase knockout.
Biotechnology and Bioengineering,2003,84:129-144
|
被引
1
次
|
|
|
|
|
14.
Stols L. Production of succinic acid through overexpression of NAD+ -dependent malic enzyme in an Escherichia coil mutant.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY,1997,63:2695-2701
|
被引
17
次
|
|
|
|
|
15.
Millard C S. Enhanced production of succinic acid by overexpression of phosphoenolpyruvate carboxylase in Escherichia coli.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY,1996,62:1808-1810
|
被引
23
次
|
|
|
|
|
16.
Lin H. Effect of Sorghum vulgare phosphoenolpyruvate carboxylase and Lactococcus lactu pyruvate carboxylase coexpressian on suocinate production in mutant strains of Escherichia coli.
Appl Microbiol Biotechnd,2005,67:515-523
|
被引
12
次
|
|
|
|
|
17.
Kim P. Effect of overexpression of Aainobacillus succinogenes phosphcenolpyruvate carboxykinase on succinate production in Escherichia coli.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2004,70:1238-1241
|
被引
17
次
|
|
|
|
|
18.
Kwon Y D. Influence of gluconeegenic phosphcenolpyruvate csrboxykinase (PCK)expression on succinic acid fermentation in Ewherichia coli under hish bicarbonate condition.
Journal of Microbiology and Biotechnology,2006,16:1448-1452
|
被引
4
次
|
|
|
|
|
19.
Kwon Y D. A Physidogy study of Eschedchia coli overexpressing phosphoenolpymvate carboxykinase.
Biotechnol Biochem,2008,72(4):1138-1141
|
被引
1
次
|
|
|
|
|
20.
Kwon Y D. The effect of NADPdependent malic enzyme expression and anaerobic C4 metabolism in Escherichia coil compared with other anaplerotic enzymes.
Journal of Applied Microbiology,2007,103:2340-2345
|
被引
5
次
|
|
|
|
|
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