痛觉感受相关的TRP离子通道蛋白研究进展
查看参考文献14篇
|
文摘
|
疼痛是机体对外界伤害性刺激产生的一种不愉快感觉,与临床上包括癌症、糖尿病、关节炎等在内的多种疾病的病理过程相关.瞬变感受器离子通道蛋白是一类非选择性阳离子通道蛋白超家族,目前已有七个亚族、30多个成员在哺乳动物中被相继发现.近年研究表明TRPV亚家族中TRPV1、TRPV2、TRPV3、TRPV4以及TRPM亚家族中 TRPM8和TRPA亚家族中TRPA1与痛觉的产生关系密切.本文主要对上述离子通道与各种伤害性刺激引起的痛觉增敏的病理机制进行简要综述. |
|
来源
|
中国疼痛医学杂志
,2009,15(1):50-53 【扩展库】
|
|
关键词
|
通道蛋白
;
阳离子
;
感受器
;
痛觉
;
TRP
;
伤害性刺激
;
亚家族
;
病理过程
|
|
地址
|
1.
中国中医科学院中药所唐氏中药研究中心, 北京, 100700
2.
中国科学院心理研究所, 北京, 100101
|
|
语种
|
中文 |
|
文献类型
|
综述型 |
|
ISSN
|
1006-9852 |
|
学科
|
基础医学 |
|
基金
|
国家自然科学基金
|
|
文献收藏号
|
CSCD:3513864
|
参考文献 共
14
共1页
|
|
1.
Clapham DE. SnapShot:mammalian TRP channels.
CELL,2007,129:220
|
被引
13
次
|
|
|
|
|
2.
Bolcskei K. Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice.
PAIN,2005,117:368-376
|
被引
13
次
|
|
|
|
|
3.
Christoph T. Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1.
Neurochem,2007,50:281-290
|
被引
2
次
|
|
|
|
|
4.
Hong S. Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1.
Journal of Biological Chemistry,2005,280:618-627
|
被引
16
次
|
|
|
|
|
5.
Rau KK. Heat sensitization in skin and muscle nociceptors expressing distinct combinations of TRPV1 and TRPV2 protein.
Journal of Neurophysiology,2007,97:2651-2662
|
被引
3
次
|
|
|
|
|
6.
Chung MK. Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel,TRPV3.
Journal of Biological Chemistry,2005,280:15928-15941
|
被引
5
次
|
|
|
|
|
7.
Hu HZ. Potentiation of TRPV3 channel function by unsaturated fatty acids.
Journal of Cellular Physiology,2006,208:201-212
|
被引
1
次
|
|
|
|
|
8.
Yoshida T. Nitric oxide activates TRP channels by cysteine S-nitrosylation.
NATURE CHEMICAL BIOLOGY,2006,2:596-607
|
被引
14
次
|
|
|
|
|
9.
Grant AD. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
JOURNAL OF PHYSIOLOGY,2007,578:715-733
|
被引
9
次
|
|
|
|
|
10.
Alessandri-Haber N. A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators.
Journal of Neuroscience,2006,26:3864-3874
|
被引
11
次
|
|
|
|
|
11.
Andersson DA. TRPM8 activation by menthol,icilin,and cold is differentially modulated by intracellular Ph.
Journal of Neuroscience,2004,24:5364-5369
|
被引
7
次
|
|
|
|
|
12.
Proudfoot CJ. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
CURRENT BIOLOGY,2006,16:1591-1605
|
被引
13
次
|
|
|
|
|
13.
Kosugi M. Activation of TRPA1 Channel Facilitates Excitatory Synaptic Transmission in Substantia Gelatinosa Neurons of the Adult Rat Spinal Cord.
Journal of Neuroscience,2007,27:4443-4451
|
被引
2
次
|
|
|
|
|
14.
Jeske NA. Cannabinoid WIN 55,212 -2 regulates TRPV1 phosphorylation in sensory neurons.
Journal of Biological Chemistry,2006,281:32879-32890
|
被引
5
次
|
|
|
|
|
了解气象卫星更多信息，请访问