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早发性抑郁及其神经基础
Early-onset Depression and Its Neural Basis

查看参考文献44篇

王玮文 1   谢希 1   邵枫 2  
文摘 儿童期和青少年期抑郁（早发性抑郁）表现出与成年期抑郁不同的一些临床症状、药物疗效和生理反应特征，导致这些差异的神经生物学基础目前尚不清楚。儿童期和青少年期神经系统的发展变化可能参与旱发性抑郁的病生理，尤其是单胺能神经递质系统结构和功能的变化与早发性抑郁的生理和药物治疗反应密切相关。旱发性抑郁动物模型的建立是研究早发性抑郁脑机制的基础，未来研究的重点是发展有效的早发性抑郁治疗药物和早期心理行为干预技术。
其他语种文摘 Childhood and adolescent depression （early-onset depression） has been found to differ from adult depression in terms of clinical features, neurobiological response and efficacy of antidepressants. The neurobiological mechanisms underlying the differences were poorly understood. Developmental transformations in brain, especially, discrepancy of the maturation of the adrenergic and serotonergic neurotransmitter systems during childhood and adolescence maybe involve in pathophysiology of early-onset depression. The establishment of depression model in childhood and adolescence animals was critical to understand the neural basis of early-onset depression and to develop successful treatment and intervention strategies.
来源 心理科学进展 ,2008,16(3):411-417 【扩展库】
关键词 儿童期 ; 青少年期 ; 旱发性抑郁 ; 单胺能神经递质
地址

1. 中国科学院心理研究所, 心理健康院重点实验室, 北京, 100101  

2. 北京大学心理学系, 北京, 100871

语种 中文
文献类型 研究性论文
ISSN 1671-3710
学科 社会科学总论
基金 国家自然科学基金 ;  中国科学院知识创新工程重要方向项目 ;  国家973计划
文献收藏号 CSCD:3291990

参考文献 共 44 共3页

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引证文献 3 篇

1 殷盛明 社会隔离对实验动物行为的影响 中华行为医学与脑科学杂志,2011,20(10):952-954
被引 5 次

2 郑莉明 中枢5-HT能系统在早发性抑郁中的作用研究 中国药理学通报,2015,31(1):19-23
被引 4 次

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