靛红衍生物的合成及其对稻瘟菌的生物活性
Synthesis of Isatin Derivatives and the Biological Activity Against the Magnaporthe grisea
查看参考文献15篇
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文摘
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以靛红为原料合成了系列3-亚胺基，亚甲基-吲哚-2-酮化合物及其Mannieh碱衍生物，研究了它们在抗稻瘟菌方面的活性，发现了这两种类型的若干化合物有较好的抑制稻瘟菌孢子萌发的活性，初步讨论了构效关系。认为1位的羟甲基和胺甲基、3位的亚甲基是药效团，芳基亚甲基苯环上对位取代基、羟基取代基和吸电子取代基不利于活性的提高，邻位的供电子取代基有利于活性的提高。 |
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其他语种文摘
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A series of 3-imine/methylene-indole-2-one compounds was synthesized from isatin, and their activity on inhibition of germination of Magnaporthe grisea spores was evaluated. It was found that the hydroxymethyl and aminomethyl of N, and the methylene on C3 might be the pharmacophore. The p-substitute, hydroxy, and electron withdraw group of the aryl methylene lead to poor activity, while the o-electron donor group leads to potent activity. |
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来源
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云南植物研究
,2007,29(6):717-721 【核心库】
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关键词
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稻瘟菌
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靛红
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药效团
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地址
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1.
中国科学院昆明植物研究所, 植物化学与西部植物资源持续利用国家重点实验室, 云南, 昆明, 650204
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贵州省中科院天然产物化学重点实验室, 中科院天然产物化学重点实验室, 贵州, 贵阳, 550002
3.
中国农业大学农学与生物技术学院, 北京, 100094
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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0253-2700 |
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学科
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植物学 |
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基金
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中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室基金
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贵州省优秀科技教育人才省长专项基金
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文献收藏号
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CSCD:3042315
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