抗生素糖基转移酶研究进展
Recent advances in antibiotic glycosyltransferases
查看参考文献34篇
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文摘
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糖苷类抗生素是临床上广泛应用的抗菌和抗肿瘤化合物.该类化合物在体内由糖基转移酶催化,糖基化反应通常在抗生素生物合成的最后发生,糖基的位置、类型和数量对糖苷类抗生素的活性有很大的影响.本文综述了糖基转移酶的种类、功能、特性及其在组合生物合成中的应用与研究前景. |
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其他语种文摘
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Glycoside antibiotics, a category of compounds widely used clinically for anti-bacterial and anti-cancer, are catalyzed by antibiotic glycosyltransferases (Gtfs) in vivo. The sugar moieties are transferred to the corresponding aglycon by Gtfs, often work at very late stages of biosynthesis of antibiotics. The position, type and number of sugar moieties incorporated to the antibiotics have great impact on its bioactivity. This article provides an overview of the categories, functions, characteristics of Gtfs, their applications in combinatorial biosynthesis, and the prospects for research. |
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来源
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中国抗生素杂志
,2007,32(5):257-262,290 【核心库】
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关键词
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抗生素的糖基转移酶
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抗生素糖苷
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糖基化
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地址
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中国科学院昆明植物研究所, 植物化学与西部植物资源持续利用国家重点实验室, 昆明, 650204
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1001-8689 |
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学科
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药学 |
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文献收藏号
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CSCD:2829901
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34
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