碳酸酐酶Ⅱ及其抑制剂研究进展
Carbonic Anhydrase Ⅱ : Structures , Functions and Inhibitors
查看参考文献52篇
文摘
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碳酸酐酶Ⅱ是一种活性中心含有Zn~(2+) 、能催化CO_2 + H_2O\ HCO_3~- + H~+ 反应的金属酶。它广泛分布于人体多种组织、器官中, 与人体酸碱平衡、青光眼、骨质疏松症、癌症等多种生理或病理过程密切相关, 多年来一直备受关注。自从1992 年高分辨率的碳酸酐酶Ⅱ 晶体结构测定以来, 其抑制剂研究发展较快, 已有活性好、选择性强的抑制剂作为新药应用于临床。本文以碳酸酐酶Ⅱ结构、功能和抑制剂研究为重点, 主要介绍近15 年来该领域研究的一些重要进展。 |
其他语种文摘
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Human carbonic anhydrase Ⅱ is one of the most efficient one in carbonic anhydrase isozymes, which catalyzes the reversible hydration dehydration of CO_2 and water : CO_2 + H_2O\HCO_3~- + H~+. It is found in virtually every tissue and cell type, and involves in many human physiological and pathological processes, such as human acid-base balance, glaucoma, osteoporosis, and cancer. Since discovered in 1940, carbonic anhydrase Ⅱ has been an important drug target with more attention. Up to now, many inhibitors were discovered including some clinical therapeutic drugs. This paper reviewed recent developments in structures, functions and inhibitors of human carbonic anhydrase Ⅱ. |
来源
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云南植物研究
,2006,28(5):543-552 【核心库】
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关键词
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碳酸酐酶Ⅱ
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结构
;
功能
;
抑制剂
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地址
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中国科学院昆明植物研究所, 植物化学与西部植物资源持续利用国家重点实验室, 云南, 昆明, 650204
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语种
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中文 |
文献类型
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研究性论文 |
ISSN
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0253-2700 |
学科
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植物学 |
基金
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中国科学院西部之光人才培养计划
;
国家自然科学基金项目
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文献收藏号
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CSCD:2572626
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