湖北地区普通人群卡波氏肉瘤相关疱疹病毒感染的血清学分析
Seroprevalence of Kaposi＇s Sarcoma-associated Herpesvirus in the General Population from Hubei Province
查看参考文献27篇
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文摘
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卡波氏肉瘤相关疱疹病毒（KsHv）可导致人类产生卡波氏肉瘤（Ks），即AIDS病人最为常见的肿瘤。广泛的流行病学研究显示，KSHV的流行与KS相似并呈现明显的地域分布型。为调查KSHV在汉族普通人群中的感染情况，我们以KSHV ORF65编码的小衣壳蛋白（sma11 capsid protein）为抗原，采用酶联免疫（ELISA）分析方法，对湖北地区560例汉族普通人群血清样品进行了KSHV抗体检测。在检测的560份血样中，KSHV抗体总阳性率为5．2％，其中，男性阳性率为5．7％，女性为4．5％。统计学分析显示，KSHV感染率在男女性别上无差异（P=0．542），但与年龄有一定的相关性：10岁以下儿童群体较之10岁以上人群KSHV感染率具有显著的统计学差异（P=0．006，OR=6．692，95％CI=1．710—26．198）：60岁以上的老年人群KSHV感染率有上升趋势，但无统计学明显差异（P=0．052）。上述结果表明，KSHV在这一地区的流行与西方成年人群的感染率相似，但在儿童群体中的相对较高的感染率与一些非洲地区的接近。由此提示在该群体可能存在特殊的传播模式。 |
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其他语种文摘
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Kaposi＇s sarcoma-associated herpes-virus （KSHV）, also known as Human herpesvirus 8 （HHV-8） is etiologically linked to the development of Kaposi＇s sarcoma（KS）, the most commonly found cancers in patients with AIDS. Extensive epidemiology studies have shown that the epidemiology of KSHV mimics that of KS displaying distinct geographic distribution patterns with low prevalence in North America and Europe, medium prevalence in Eastern European and Mediterranean regions, and high prevalence in some regions in Africa. However, the prevalence of KSHV infection in Asia, especially in China remains undefined. To investigate the prevalence of KSHV infection from the general population in the Han nationality from Hubei Province, we examined 560 sera specimens using an ELISA-based assay that measured antibodies to KSHV lytic antigen small capsid protein ORF65. The overall KSHV seroprevalence in this population was 5.2%. There was no difference between male and female （5.7% vs 4.5%, P = 0.542）. On the other hand, the age distribution pattern was peculiar. KSHV-seropositive rate was significantly higher in subjects younger than 10 years old （P = 0.006, OR = 6.692, 95% CI： 1.710-26.198）. Excluding this group, KSHV-seropositive rate showed a trend of increase with age but it was not statistically significant. Our results indicate that the prevalence of KSHV infection is similar to those reported in Western countries in the adult population. However, the relative high prevalence of KSHV infection among the young children is reminiscent of some African regions, and might implicate specific mode of transmission in this population. |
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来源
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中国病毒学
,2006,21(2):97-101 【核心库】
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关键词
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卡波氏肉瘤
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卡波氏肉瘤相关疱疹病毒（KSHV）
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疱疹病毒8型
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血清学检测
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地址
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中国科学院武汉病毒研究所, 病毒学国家重点实验室, 湖北, 武汉, 430071
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1003-5125 |
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学科
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内科学 |
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基金
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国家自然科学基金海外青年学者合作研究基金
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国家自然科学基金资助项目
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中国科学院王宽诚教育基金
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文献收藏号
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CSCD:2338991
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