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大肠癌中β-catenin表达及与COX-2、VEGF表达的关系
Expression of β-catenin in Human Colorectal Carcinoma and Its Relationship to Expression of COX-2 with VEGF
查看参考文献10篇
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文摘
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目的探讨大肠癌组织中β-catenin的异常表达的意义及与COX-2、VEGF表达的关系。方法应用免疫组化SP法检测78例大肠癌组织和15例癌旁正常粘膜组织中β-catenin、COX-2、VEGF的表达。结果β-catenin在15例正常组织均呈正常表达，而COX-2和VEGF均呈阴性。大肠癌中伊catenin异常表达率为75．6％，COX-2和VEGF阳性表达率分别为65．4％、7（1．5％。β-catenin异常表达与大肠癌的分化程度、转移和Dukes’分期显著相关（P〈0.15）。COX-2、VEGF表达水平与大肠癌转移、Duke’s分期有统计相关性（P〈0.05）。β-catenin异常表达与COX-2和VEGF的表达在大肠癌中均有显著的正相关性（P〈0.05，r=0．278、0．419）。结论β-catenin在胞浆或胞核内的异常聚集以及COX-2和VEGF的过度表达共同参与大肠癌的进展。 |
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其他语种文摘
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Objective To investigate the replationship between the abnormal expression of ffcatenin and the high expression of COX-2 and VEGF and its significance. Methods The expression of ffcatenin and COX-2 and VEGF were detected in 78 cases of colorectal carcinoma and 15 cases of normal colorectal mucous tissues around the loci by immunohistochemical method. Results β-catenin was expressed normally in 15 cases of the normal colorectal mucous tissue,while COX-2 and VEGF were negative. The expression rate of COX-2 , VEGF was 65. 4%, 70. 5%, And the abnormal expression rate of β-catenin was 75.6% in the tissue of colorectal carcinoma. The abnormal expression rate of β-catenin was correlated with the extent of proliferation, Duke＇s stage and metastasis of lymph node（P〈0.05）. COX-2 and VEGF positive expression were correlation with the lymoh node metastasis and Duke＇s staging（P〈0. 05）. The abnormal expression of ffcatenin and the positive expression of COX2 and VEGF had a parallel relationship in colorectal carcinoma（P〈0. 05,r =0. 278,0. 419）. Conclusion β-catenin accumulation in the cytoplasm/nuclear and the high expression of COX-2 and VEGF have synergistic effect on the progression of colorectal carcinoma. |
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来源
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肿瘤防治研究
,2006,33(1):20-22 【扩展库】
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关键词
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β-catenin
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COX-2
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VEGF大肠癌
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免疫组织化学
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地址
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武汉大学中南医院肿瘤科, 430071
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1000-8578 |
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学科
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肿瘤学 |
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文献收藏号
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CSCD:2321679
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