异生物素及其代谢物在反刍动物体组织的吸收、运转与分布
Absorption, transformation and distribution of xenobiotics and their metabolites in ruminants tissues
查看参考文献69篇
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文摘
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消化道中的芳香族和脂环族异生物素通过被动扩散穿过细胞内通道胞膜而被上皮层吸收．吸收后一进入血液立即与血液成分如蛋白质（主要为自蛋白）和红细胞结合；其结合限制了异生物素在血液与细胞内环境之间的分布，有利于异生物素达到代谢场所（主要是肝脏），通过一个双阶段的反应过程，异生物素失活；芳香族和脂环族化合物在体组织中的氧化反应主要有α、β氧化反应和芳构化反应，通过共轭反应，异生物素降低了脂溶性而能够通过尿液排泄；异生物素的共轭反应主要有与葡萄糖苷酸共轭、与硫酸共轭、与氨基酸共轭3种途径．而这3种途径之间对底物存在竞争机制。 |
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其他语种文摘
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Xenobiotics such as aromatic and alicyclic compounds are mainly absorbed in the gut through the epi thelial layer by passive diffusion across the membranes of the intracellular channel. Once the xenobiotics have entered the blood, they conjugate instantly with blood constituents such as protein and red cells, especially albumin. As a consequence,the conjugation limits the distribution of the xenobiotics between blood and the intercel lular environment and facilitates their migration to the sites of metabolism, the main one of which is the liver. The deactivation of xenobiotics in animals occurs by a biphasic process. Xenobiotic aromatic and alicyclie compounds reactions involve α-,β oxidations and aromatisation, By conjugation,thc xenobiotics reduce lipid solubili ty which makes urinary excretion possible. The three main conjugating pathways between competing substrates are glucuronide, amino acid and sulphuric acid conjugations. |
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来源
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草业学报
,2006,15(1):1-8 【核心库】
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关键词
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反刍动物
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异生物索
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体组织
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吸收
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分布
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运转
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地址
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1.
中国科学院西北高原生物研究所, 青海, 西宁, 810008
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甘肃农业大学草业学院, 甘肃, 兰州, 730070
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北京师范大学资源科学研究所, 北京, 100875
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Universidad Nacional de Le Pampa, Argentina
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1004-5759 |
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学科
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畜牧、动物医学、狩猎、蚕、蜂 |
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基金
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中国科学院“百人计划”项目
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国家教育部高等学校优秀青年教师教学科研奖励计划
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文献收藏号
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CSCD:2318808
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参考文献 共
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